To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.

All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.

All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores.

Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours.

CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.

Inclusion Criteria:

• no prior diagnosis of acute pancreatitis
• admission to the hospital within 2 days since the clinical symptoms
• confirmed diagnosis of acute pancreatitis

Exclusion Criteria:

• chronic pancreatitis
• pancreatic cancer

All patients admitted to the hospital within 48 hours since the typical symptoms of acute pancreatitis

We plan to share the data and recruitment status when the study reaches its requirement sample size