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our practice for the past 10 years we have noticed a transitional impairment of liver function (elevated liver enzymes, total and direct bilirubin, and elevated serum lactate levels) following donors' liver resection. Several drugs have been investigation on liver regeneration , proven benefit of N-Acetylcysteine (NAC) on rats with steatohpatitis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| NAC group | Active Comparator | Group NC received NAC 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days |
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| Control group | Placebo Comparator | Group C (Control group) will receive ringer acetate continuous infusion at same rate for 2 days. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| N-Acetylecysteine | Drug | N-Acetylecysteine 150 mg/kg diluted in 100 ml glucose 5 % over 40 minutes followed by NAC 12.5 mg/kg in 500 ml glucose 5% over 4 hours, followed by NAC 6.25 mg/kg for 2 postoperative days |
| Measure | Description | Time Frame |
|---|---|---|
| Serum lactate | 24 hours postoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine | Cairo | Egypt |
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| Placebo | Drug | Ringer acetate continuous infusion at the same rate for 2 days. |
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