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The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No study intervention | No study intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levetiracetam | Drug | Standard of care |
| |
| Lacosamide |
| Measure | Description | Time Frame |
|---|---|---|
| Influence of renal replacement therapy on drug exposure (AUC of plasma concentration levels) | Simultaneous samples will be taken from pre-filter, post-filter, and effluent sampling ports before dose administration, after the completion of the infusion or 1 hours post oral dose, and 6 additional time points post-infusion or post oral administration. | Single Dosing Interval - 12 hours |
| Influence of renal replacement therapy on drug clearance | Simultaneous samples will be taken from pre-filter, post-filter, and effluent sampling ports before dose administration, after the completion of the infusion or 1 hours post oral dose, and 6 additional time points post-infusion or post oral administration. | Single Dosing Interval - 12 hours |
| Determination of drug specific sieving coefficient (SC) | SC is a measure of a filter efficiency in clearing drugs and solute. SC will be calculated using pre-filter and effluent concentrations | Single Dosing Interval - 12 hours |
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Inclusion Criteria:
Exclusion Criteria:
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All patients undergoing CRRT who are also being treated with an antiepileptic drug
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| Name | Affiliation | Role |
|---|---|---|
| Neeraj Badjatia, MD | University of Maryland, College Park | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | United States |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D051437 | Renal Insufficiency |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D000077287 | Levetiracetam |
| D000078334 | Lacosamide |
| D010672 | Phenytoin |
| D010634 | Phenobarbital |
| D007649 | Ketamine |
| D014635 | Valproic Acid |
| ID | Term |
|---|---|
| D000081 | Acetamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000085 | Acetates |
| D000144 |
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| Drug |
Standard of care |
|
| Phenytoin | Drug | Standard of care |
|
| Phenobarbital | Drug | Standard of care |
|
| Ketamine | Drug | Standard of care |
|
| Valproic Acid | Drug | Standard of care |
|
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D011760 | Pyrrolidinones |
| D011759 | Pyrrolidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006827 | Hydantoins |
| D048289 | Imidazolidines |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D001463 | Barbiturates |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D010421 | Pentanoic Acids |
| D014631 | Valerates |
| D005232 | Fatty Acids, Volatile |
| D005227 | Fatty Acids |
| D008055 | Lipids |