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The finding that the combination of the inactivated probiotic Bifidobacterium Lactis (BPL1), inulin as a source of soluble fiber and omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in a surimi matrix has positive effects on visceral adiposity , insulin resistance and plasma tryclycerides in a preclinical model of rats that present obesity induced by diet is the basis of the present hypothesis. This finding is based on the fact that these three bioactive compounds exert these effects through sensibly different and complementary mechanisms, which suggests that their combined use may have synergistic effects.
On this basis the present hypothesis is posed: the consumption of surimi enriched with inactivated probiotic BPL1, inulin and omega-3 fatty acids, in the same doses that have been effective in obese rats (SIAP), can induce a reduction of more than 5% of visceral adipose tissue, being clinically relevant in people with abdominal obesity.
If the effect on abdominal obesity is associated or not with a lower glycemia and / or absorption of fats induced by the consumption of surimi can be evaluated by monitoring these parameters for 4 hours after the ingestion of a breakfast high in fat.
The main objective of this study was to evaluate the effects of the consumption of surimi enriched with the probiotic BPL1, inulin and omega-3 fatty acids, on visceral abdominal adiposity in people with abdominal obesity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator |
| |
| Surimi intervention | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Surimi intervention | Combination Product | The bioactive compounds used to obtain the surimi product are:
It was a 3 months nutritional intervention. Volunteers will eat 50g per day of enriched surimi. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in abdominal visceral fat (measured in mm2) | measured by magnetic resonance imaging (MRI), transverse body scan in one axial slice 5 cm over L5-S1. | 12 weeks, week 1 and week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in parameters of body composition (weight, measured in kg) | Trained dieticians measure weight using a body composition analyzer (Tanita SC 330-S; Tanita Corp., Barcelona, Spain). | 12 weeks, week 1 and week 12 |
| Changes in parameters of body composition (height, measured in meters) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centro Tecnológico de Nutrición y Salud (Eurecat-Reus) | Reus | Tarragona | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35643872 | Derived | Companys J, Calderon-Perez L, Pla-Paga L, Llaurado E, Sandoval-Ramirez BA, Gosalbes MJ, Arregui A, Barandiaran M, Caimari A, Del Bas JM, Arola L, Valls RM, Sola R, Pedret A. Effects of enriched seafood sticks (heat-inactivated B. animalis subsp. lactis CECT 8145, inulin, omega-3) on cardiometabolic risk factors and gut microbiota in abdominally obese subjects: randomized controlled trial. Eur J Nutr. 2022 Oct;61(7):3597-3611. doi: 10.1007/s00394-022-02904-0. Epub 2022 May 28. |
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| ID | Term |
|---|---|
| D056128 | Obesity, Abdominal |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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|
| Placebo | Combination Product | Conventional surimi It was a 3 months nutritional intervention. Volunteers will eat 50g per day of conventional surimi. |
|
Trained dieticians measure height using a well mounted stadiometer (Tanita Leicester Portable; Tanita Corp., Barcelona, Spain) |
| 12 weeks, week 1 |
| Changes in parameters of body composition (BMI) | Body mass index (BMI) is calculated as the ratio between measured weight (kg)/and the square of height (m). | 12 weeks, week 1 and week 12 |
| Changes in parameters of body composition (waist circumference, measured in centimeters) | Waist circumference (WC) is measured at the umbilicus using a 150 cm anthropometric steel measuring tape. | 12 weeks, week 1 and week 12 |
| Changes in blood pressure (measured in mmHg) | Systolic and diastolic blood pressure (SBP and DBP) are measured twice after 2-5 minutes of patient respite, seated, with one-minute interval in between, using an automatic sphygmomanometer (OMRON HEM-907; Peroxfarma, Barcelona, Spain). | 12 weeks, week 1 and week 12 |
| Changes in plasmatic parameters (glucose, total cholesterol, LDL and HDL cholesterol, triglycerides, non-esterified fatty acids, Apo B100, Apo A1 and Insulin, measured in mg/dL) | Serum lipids and apolipoproteins, non-esterified fatty acids, glucose, and insulin concentrations are measured in serum by standardized enzymatic automated methods in an autoanalyzer (Beckman Coulter-Synchron, Galway, Ireland). LDL-c is calculated by the Friedewald formula. | 12 weeks, week 1 and week 12 |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |