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The purpose of this study is to evaluate the Pharmacokinetics and safety/tolerability between Fimasartan/Amlodipine/Hydrochlorothiazide and co administration of Fimasartan/Amlodipine and Hydrochlorothiazide in Healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence A | Experimental | Period 1(Treatment R) - Period 2(Treatment R) - Period 3(Treatment T) There will be a 14 washout of days between the each period. |
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| Sequence B | Experimental | Period 1(Treatment R) - Period 2(Treatment T) - Period 3(Treatment R) There will be a 14 washout of days between the each period. |
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| Sequence C | Experimental | Period 1(Treatment T) - Period 2(Treatment R) - Period 3(Treatment R) There will be a 14 washout of days between the each period. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Treatment T | Drug | Fixed dose Combination of Fimasartan/Amlodipine/Hydrochlorothiazide |
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| Measure | Description | Time Frame |
|---|---|---|
| Cmax | Maximum Concentration of Fimasartan, Amlodipine, Hydrochlorothiazide in plasma | 0~144hours after Medication |
| Measure | Description | Time Frame |
|---|---|---|
| AUCinf | "Area under the plasma concentration versus time curve " of Fimasartan, Amlodipine, Hydrochlorothiazide | 0~144hours after medication |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kyung-sang Yu | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | Jongno-gu | 100-744 | South Korea |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Treatment R | Drug | Co-administration of Fimasartan/Amlodipine and Hydrochlorothiazide |
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