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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A03527-46 | Other Identifier | ANSM |
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The investigators hypothesize that a primary embolization, 3-4 weeks before surgery, would allow development of vascular collaterality, in particular for the marginal artery which will ensure a better colonic perfusion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| embolization | Experimental |
| |
| No embolization | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| embolization of the inferior mesenteric artery | Procedure | proximal occlusion of the inferior mesenteric artery, before its divisional branches, by coils or plug 3-4 weeks prior to surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Oxygen saturation of the colon after inferior mesenteric artery ligation between groups | Digital oxymeter (%) | Prior to start of surgery |
| Arterial pressure after inferior mesenteric artery ligation between groups | Average (mmHg) | Prior to start of surgery |
| Colonic perfusion in the marginal artery after inferior mesenteric artery ligation between groups | Rectal resistance index measured by Doppler | Prior to start of surgery |
| Oxygen saturation of the colon after inferior mesenteric artery ligation between groups | Digital oxymeter (%) | 60 seconds after surgery |
| Oxygen saturation of the colon after inferior mesenteric artery ligation between groups | Digital oxymeter (%) | 5 minutes after surgery |
| Arterial pressure in the marginal artery after inferior mesenteric artery ligation between groups | Average (mmHg) | 60 seconds after surgery |
| Arterial pressure in the marginal artery after inferior mesenteric artery ligation between groups | Average (mmHg) | 5 minutes after surgery |
| Colonic perfusion in the marginal artery after inferior mesenteric artery ligation between groups |
| Measure | Description | Time Frame |
|---|---|---|
| Presence of post-embolization complications | Yes/No | Day 5 post-emoblization |
| Presence of post-surgery complications | Yes/No | Hospital discharge (Day 7 after surgery) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Martin Bertrand, MD | CHU Nimes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Nimes | Nîmes | 30029 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35333313 | Result | Frandon J, Berny L, Prudhomme M, de Forges H, Serrand C, de Oliveira F, Beregi JP, Bertrand MM. Inferior mesenteric artery embolization ahead of rectal cancer surgery: AMIREMBOL pilot study. Br J Surg. 2022 Jul 15;109(8):650-652. doi: 10.1093/bjs/znac071. |
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| Inferior mesenteric artery ligation | Procedure | Endovascular ligation of Inferior mesenteric artery |
|
Rectal resistance index measured by Doppler |
| 60 seconds after surgery |
| Colonic perfusion in the marginal artery after inferior mesenteric artery ligation between groups | Rectal resistance index measured by Doppler | 5 minutes after surgery |
| ID | Term |
|---|---|
| D012811 | Sigmoid Neoplasms |
| D012004 | Rectal Neoplasms |
| ID | Term |
|---|---|
| D003110 | Colonic Neoplasms |
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012810 | Sigmoid Diseases |
| D012002 | Rectal Diseases |
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