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Chronic obstructive pulmonary disease (COPD) is characterised by non-reversible bronchial obstruction associated with systemic disorders and comorbid factors. Dyspnoea is a common symptom among patients with Chronic Obstructive pulmonary Disease (COPD). Dyspnea is the primary symptom limiting exercise and daily activities in these patients. It has been reported that breathing cold air could decrease dyspnoea induced by exercise and could improve exercise performance. The aim of this study is to carry out the effect of cooling sensation induced by menthol chewing-gum on dyspnoea and exercise performance among patients with COPD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test with Menthol | Experimental | Patients will chew a menthol flavored chewing gum 5 minutes before perform one Six-minute Walk Test |
|
| Test with placebo | Placebo Comparator | Patients will chew a strawberry flavored chewing gum 5 minutes before perform one Six-minute Walk Test |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Test with Menthol | Other | patients will perform a Six-minute walk test according to American Thoracic Society guidelines |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Dyspnea after each tests | Change in dyspnea using Modified Borg Scale (0 - 10 points) 0=no dyspnea ; 10 = maximal effort | The outcome will be measured before and at the end of the test, the two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in respiratory rate | Change in respiratory rate (cycles per minute) will be measured breath-by-breath using a Respiratory Inductive Plethysmography | Data will be continuously collected during every tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Guillaume Prieur | Groupe Hospitalier du Havre | Principal Investigator |
| Marc Beaumont | Centre Hospitalier des Pays de Morlaix | Principal Investigator |
| Mathieu Delorme | Resp'Air, Talence | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre hospitalier des Pays de Morlaix | Morlaix | Brittany Region | 29672 | France | ||
| Resp'Air |
Data type : deidentified participtant data
after publication
the request shall be sent to Guillaume Prieur (gprieur.kine@gmail.com)
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D004417 | Dyspnea |
| D008171 | Lung Diseases |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
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| ID | Term |
|---|---|
| D008610 | Menthol |
| ID | Term |
|---|---|
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 |
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| Test with placebo | Other | patients will perform a Six-minute walk test according to American Thoracic Society guidelines |
|
| Change in inspiratory capacity |
Change in inspiratory capacity (Liters) will be measured using a portable spirometer |
| The outcome will be measured before and at the end of the test, the two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day. |
| Change in Cardiac Frequency | Change in Cardiac Frequence (bpm) using a pulse oximetry | Data will be continuously collected during every tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day. |
| Change in Oxygen Saturation | Change in Oxygen Saturation (%) using a pulse oximetry | Data will be continuously collected during every tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day. |
| Change in tidal volume | Change in tidal volume (Liters) will be measured breath-by-breath using a portable spirometer | The outcome will be measured before and at the end of the test, the two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day. |
| Change in 6-min walk distance | Change in 6-min walk distance (meters). | The outcome will be measured at the end of each tests. The two six-minute walk test will perform the same day, separate from 30 minutes minimum for a total time frame of 1 day. |
| Talence |
| New Aquitaine |
| 33400 |
| France |
| Groupe Hospitalier du Havre | Le Havre | Normandy | 76290 | France |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012120 | Respiration Disorders |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D001519 | Behavior |
| Organic Chemicals |
| D000081005 | Cyclohexane Monoterpenes |
| D003510 | Cyclohexanes |
| D003516 | Cycloparaffins |
| D006840 | Hydrocarbons, Alicyclic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D039821 | Monoterpenes |
| D013729 | Terpenes |
| D008055 | Lipids |