| Primary | Change in Self-selected Gait Speed (Normalized) | Calculated from the 10 meter walk test in meters/second at self-selected speed and then normalized by stature to yield non-dimensional units. Higher values represent faster gait speeds. | The a priori analytic approach included all participants in the primary analysis with the first (baseline) and second assessments. Least squares (LS) means adjusted for baseline and 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | dimensionless | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
| | | Title | Denominators | Categories |
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| | | Title | Measurements |
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| - OG000-0.0010± 0.0096
- OG0010.0163± 0.0100
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| Primary | Change in Fast Gait Speed (Normalized) | Calculated from the 10 meter walk test in meters/second at fast walking speed and then normalized by stature to yield non-dimensional units. Higher values equal faster gait speeds. | The a priori analytic approach included all participants in the primary analysis with the first (baseline) and second assessments. LS Means adjusted for baseline and 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | dimensionless | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Primary | Change in Peak Power | Lower extremity peak power produced during a power leg press test averaged over 5 trials; product of force x velocity; adjusted for sled angle and body mass | The a priori analytic approach included all participants in the primary analysis with the first (baseline) and second assessments. LS Means adjusted for 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | watts | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Primary | Change in Average Strides Per Day | Average number of strides walked per day captured by Step Watch accelerometer as worn for a minimum of 4 days | The a priori analytic approach included all participants in the primary analysis with the first (baseline) and second assessments. LS Means adjusted for 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | strides/day | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Self-selected Gait Speed (Normalized) | Calculated from the 10 meter walk test in meters/second at self-selected speed and then normalized by stature to yield non-dimensional units. Higher values equal faster speeds. | LS Means adjusted for baseline and 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | dimensionless | | Baseline and 2 months post training (16 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Fast Gait Speed (Normalized) | Calculated from the 10 meter walk test in meters/second at fast walking speed and then normalized by stature to yield non-dimensional units. Higher values equal faster speeds. | LS Means adjusted for baseline and 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | dimensionless | | Baseline and 2 months post training (16 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Peak Power | Lower extremity peak power produced during a power leg press test averaged over 5 trials; product of force x velocity; adjusted for sled angle and body mass | LS Means adjusted for 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | watts | | Baseline and 2 months post training (16 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Average Strides Per Day | Average number of strides walked per day captured by Step Watch accelerometer as worn for a minimum of 4 days | LS Means adjusted for 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | strides/day | | Baseline and 2 months post training (16 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in One Minute Walk Test | Distance covered while walking as fast as possible for 1 minute measured in meters | LS Means adjusted for baseline and 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | meters | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Cross-sectional Area | Cross-sectional area of rectus femoris taken at 50% distance between anterior superior iliac spine and apex of patella using 2D Bmode Ultrasound imaging in cm^2; Average of Right and Left Sides | LS Means adjusted for 3 covariates (Age group; Site; GMFCS level) and side tested (left and right) | Posted | | Least Squares Mean | Standard Error | cm^2 | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Isokinetic Muscle Strength of Knee Extensors | Isokinetic dynamometer (Biodex System 3/4) according to published standard procedures for isokinetic strength. Calculated for knee extensors at 60 degrees/second in newton-meters | LS means adjusted for 3 covariates (Age group; Site; GMFCS level) and side tested (left and right) | Posted | | Least Squares Mean | Standard Error | Nm | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Walking Intensity at Medium and High Stride Rates (Strides/Minute) | Average strides/day at medium (31 to 60 stride/min) and high (> 60 stride/min) stride rates as captured by Step Watch accelerometer as worn for a minimum of 4 days | LS Means adjusted for 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | strides/minute | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in Patient-Reported Outcomes Measurement Information System Physical Function-Mobility (PROMIS v2.0 Pediatric Profile 49 - Physical Function-Mobility) | Patient-Reported Outcomes Measurement Information System (PROMIS); The PROMIS item bank was developed from patient-reported outcome measures that indicate patients' state of well-being and functional abilities. The results of the Physical Function-Mobility domain are reported here as the Change in the T-score from baseline to 8-10wks post baseline. The T-score is a standardized T-score with a mean of 50 and a standard deviation (SD) of 10. Therefore, a person with a T-score of 40 is one SD below the mean. A higher PROMIS T-score represents more of the concept being measured so for a positive concept, such as Physical Function-Mobility, a higher T-score or 'change' in the T-score represents higher physical functioning and mobility. | Least squares (LS) means adjusted for 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | T-score | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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| Secondary | Change in 1RM (Muscle Strength) | 1repetition maximum (1RM) testing on a leg press reported in lbs; external load reported after adjusting for the angle of the press | LS Means adjusted for baseline and 3 covariates (Age group; Site; GMFCS level) | Posted | | Least Squares Mean | Standard Error | lbs | | Baseline and immediate post training (8-10 weeks post baseline) | | | | ID | Title | Description |
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| OG000 | PT³ (Power Training Combined With Interval Treadmill Training) | Power Training combined with interval treadmill training Power training combined with interval treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors according to resistance training guidelines for muscle power training. The interval treadmill training portion will include short-bursts (30 seconds) of high speed walking intervals alternating with 30 seconds of low to moderate speed walking for a total of 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. | | OG001 | Traditional Training (Strength Training Combined With Treadmill Training) | Strength training combined with traditional treadmill training Strength training combined with traditional treadmill training: Training will consist of unilateral and bilateral leg presses, targeting the quadriceps, hip extensors, and plantarflexors following the dosing and resistance training guidelines for muscle strength. Traditional treadmill training will consist of walking at steady-state speeds for 30 minutes. Participants will train 3 x per week for 8 weeks. Total duration of each session will be approximately 1 hour. |
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