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The prevalence of thyroid cancer has increased in recent decades. Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. This is a prospective, observational study, aiming to observe the difference of metabolic profiles between patients choose Thyrogen® injection and Eltroxin® withdrawal.
Inclusion : Patient number: 500人
Inclusion criteria :
Exclusion criteria:
Method: We will collect 20cc blood and 20 cc urine before and after radioiodine therapy during each visit (total 3 visits) and check lipid profiles, glucose profiles and inflammation markers. We will compare the difference between results of patients undergoing Thyrogen® injection and Eltroxin® withdrawal.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| radioiodine | Radiation | Patients with thyroid cancer need to choose between Thyrogen® injection and Eltroxin® withdrawal before radioiodine therapy or scan. |
| Measure | Description | Time Frame |
|---|---|---|
| Zung's Self-reported depression scale | Depression symtpoms | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Brain-derived neurotrophic factor | BDNF | 1 month |
| orexin | An associated factor for depression | 1 month |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with diagnosis of thyroid cancer
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Endocrinology and Metabolism in Taichung Veterans General Hospital | Taichung | 407 | Taiwan |
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| ID | Term |
|---|---|
| D013964 | Thyroid Neoplasms |
| ID | Term |
|---|---|
| D004701 | Endocrine Gland Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006258 | Head and Neck Neoplasms |
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| ID | Term |
|---|---|
| C000614965 | Iodine-131 |
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| Body composition | Fat component percentage to lean mass percentage ratio | 1 months |
| VCAM-1 | adhesion molecules | 1 months |
| CRP | inflammation marker | 1 months |
| Metabolic syndrome | The number of conponents for metabolic syndrome | 1 months |
| Insulin resistance | HOMA-IR | 1 month |
| D004700 |
| Endocrine System Diseases |
| D013959 | Thyroid Diseases |