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To investigate the effect of vestibular rehabilitation, with or without medication, on resolving residual dizziness after successful repositioning maneuvers in patients with benign paroxysmal positional.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Group A will be provided with Exercise-based vestibular rehabilitation (VR) twice per day for a period of 4 weeks; |
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| Group B | Experimental | Group B will be prescribed with Betahistine 12mg, twice daily for 7 days; |
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| Group C | Experimental | Group C will receive an combination of Exercise-based VR plus Betahistine. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Betahistine | Drug | Betahistine is used in the treatment of and vertigo. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Balance function | Balance function, measured by computerized dynamic posturography. | Change from baseline, at 4 weeks, 8 weeks and 12 weeks postrandomisation |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of RD symptoms | Patients self-reported days for RD onset to disappear | Change from baseline at 4 weeks, 8 weeks and 12 weeks postrandomisation. |
| Quality of life assessment scale | Measured by Dizziness and Handicap Inventory |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Huawei Li | Contact | +86-13524844652 | hwli@shmu.edu.cn | |
| Peixia Wu | Contact | 13524844652@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, China | Recruiting | Shanghai | Shanghai Municipality | 200031 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31217316 | Derived | Wu P, Cao W, Hu Y, Li H. Effects of vestibular rehabilitation, with or without betahistine, on managing residual dizziness after successful repositioning manoeuvres in patients with benign paroxysmal positional vertigo: a protocol for a randomised controlled trial. BMJ Open. 2019 Jun 18;9(6):e026711. doi: 10.1136/bmjopen-2018-026711. |
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| ID | Term |
|---|---|
| D015837 | Vestibular Diseases |
| ID | Term |
|---|---|
| D007759 | Labyrinth Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
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| ID | Term |
|---|---|
| D001621 | Betahistine |
| ID | Term |
|---|---|
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Exercise-based vestibular rehabilitation |
| Behavioral |
Exercise-based vestibular rehabilitation (VR) has proven to be an effective way for managing dizziness by relieving symptoms and improving balance and postural stability. |
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| Change from baseline at 4 weeks, 8 weeks and 12 weeks postrandomisation. |
| Otolith function | Analyzed as vestibular evoked myogenic potenials (VEMPs) | Change from baseline at 4 weeks, 8 weeks and 12 weeks follow-up will be necessary only when the previous examine showing abnormal. |
| Daily function | Daily function quantified by Vestibular Activities and Participation (VAP) questionnaire. | Change from baseline, at 4 weeks, 8 weeks and 12 weeks postrandomisation |