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Iron-deficient anaemic subjects are likely to benefit most from oral iron supplements, but supplementation schedules vary widely in clinical practice, absorption is low and compliance is poor due to mild gastrointestinal side effects. The investigators will compare iron absorption from labeled oral iron doses of 100mg and 200mg administered either on two consecutive days or on alternate days in young anemic women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stable isotope labeled iron II sulfate | All subjects will go through two iron absorption study cycles. In one cycle they get 100mg oral iron labeled with stable isotopes on two consecutive and on one alternate day and in another cycle they get 200mg oral iron labeled with stable isotopes on two consecutive and on one alternate day. Half of the subjects start with the 100mg cycle whereas the other half starts with the 200mg cycle. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Iron stable isotope labeled iron(II) sulfate | Other | Administration of oral stable isotope labels using different dosings and different regimens in women with iron deficiency anemia |
| Measure | Description | Time Frame |
|---|---|---|
| Fractional and total iron absorption | Fractional and total iron absorption from different supplementation regimens | absorption will be measured 14days after the 100mg and 200mg cycle |
| Serum hepcidin | Serum hepcidin after the administration of different doses and using different regimens | right before the administration of an iron dose |
| Serum EPO | Serum EPO after the administration of different doses and using different | right before the administration of an iron dose |
| Measure | Description | Time Frame |
|---|---|---|
| Serum ferritin | Determination of iron status | right before the administration of an iron dose |
| Serum TfR | Determination of iron status |
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Inclusion Criteria:
Exclusion Criteria:
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Young women with iron-deficiency anemia
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Human Nutrition Laboratory ETH Zurich | Zurich | 8092 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31413088 | Derived | Stoffel NU, Zeder C, Brittenham GM, Moretti D, Zimmermann MB. Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women. Haematologica. 2020 May;105(5):1232-1239. doi: 10.3324/haematol.2019.220830. Epub 2019 Aug 14. |
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| ID | Term |
|---|---|
| D018798 | Anemia, Iron-Deficiency |
| ID | Term |
|---|---|
| D000747 | Anemia, Hypochromic |
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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| ID | Term |
|---|---|
| D013431 | Sulfates |
| ID | Term |
|---|---|
| D000838 | Anions |
| D007477 | Ions |
| D004573 | Electrolytes |
| D007287 | Inorganic Chemicals |
| D013464 |
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| right before the administration of an iron dose |
| Serum CRP | Determination of inflammation status | right before the administration of an iron dose |
| Serum AGP | Determination of inflammation status | right before the administration of an iron dose |
| Serum iron | Determination of iron status | right before the administration of an iron dose |
| Total iron binding capacity | Determination of iron status | right before the administration of an iron dose |
| D000090463 |
| Iron Deficiencies |
| D019189 | Iron Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |