Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received antioxidant therapy daily for 3 months. Results are noted and analysed.

Both groups represent patients with procedures already ongoing, and with diagnosed poor or depleted ovarian reserve.

The analysis has been made to compare the efficacy of both procedures.

The bioestimulation group received a blood rich platelet therapy monthly for three months, with a technique developed by the laboratory. The second group of antioxidants received a combination of antioxidants monthly for three months. Both groups were compared to assess the results in terms of ovarian response (number of astral follicles, AMH levels, FSH, LH), and egg quality, embryo development, implantation rate, and successful pregnancy with healthy live birth.

Inclusion Criteria:

• Age between 38 and 46 years
• FSH> 12 mIU
• Estradiol > 100 pg/ml
• AMH < 0.8 ng/mL

Exclusion Criteria:

• Pelvic inflammatory syndrome
• vaginal pathologies
• known history of hyperandrogenism
• diagnosed platelet disorders as adhesion
• aggregation
• disorder of thromboxane synthesis.

Still deciding if sharing information. It can be shared as long as it does not contain personal identification such as name, and contact details. We might share the rest of information to other scientist studying the same area of low-depleted ovarian reserve and bio-stimulation techniques.