Vertebral compression fractures in osteoporotic patients is a major healthcare problem. Percutaneous vertebroplasty is commonly used to restore stability of the vertebra and to alleviate pain. However, the anesthetic techniques commonly used during these procedures such general anesthesia or a combination of local anesthesia and sedation are not satisfying as they are associated either with side effects or insufficient pain reduction.

This study compares the standard procedure of local anesthesia to a new technique of fluoroscopy-guided epidural anesthesia carried out by the radiologist.

The investigator's hypothesis is that fluoroscopy-guided epidural anesthesia

• provides better pain relief during the injection of high viscosity cement
• and thus, reduces the need of additional intravenous analgesia by remifentanil (morphine analogue)
• minimizes remifentanil potential adverse effects such as respiratory depression, hypoxemia, pruritus and nausea
• improves working conditions and satisfaction of the radiologist
• improves the global satisfaction of the patient

It is a monocentric, prospective, comparative and randomized study.

Inclusion Criteria:

• - Two osteoporotic vertebra compression fractures in the low thoracic or lumbar spine
• men and women > 18 years old
• patients with healthcare insurance
• signed and dated informed consent

Exclusion Criteria:

• men and women < 18 years
• pregnant or breastfeeding women
• patients under trusteeship or guardianship or patients under the protection of court
• bad comprehension or cooperation
• bleeding disorders
• local or general infection
• intracerebral or severe cardiac affections