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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2018-01510 | Other Identifier | NCI CTRP | |
| P30CA016059 | U.S. NIH Grant/Contract | View source | |
| HM20009089 | Other Identifier | IRB No. |
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COVID-19 Pandemic
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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The purpose of this pilot research is to study brown adipose tissue, a type of fat that increases metabolism (burns energy) during exposure to cold, and how it may contribute to the weight loss observed in cancer.
The purpose of this research is to study brown adipose tissue, a type of fat that increases metabolism (burns energy) during exposure to cold, and how it may contribute to the weight loss observed in cancer. Many patients affected by cancer lose weight, despite normal or increased nutrition. It may progress to the condition called "cancer-associated cachexia." Cancer associated cachexia is defined by an ongoing loss of skeletal muscle mass with or without the loss of fat mass, and may negatively affect quality of life and the ability to undergo cancer treatments. Metabolism is the breakdown of food by the body into the energy that your body needs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Brown Adipose Tissue Positive patients | Patients with known malignancy and incidental finding of positron emission tomography/ computerized tomography (PET/CT) scans positive for brown adipose tissue (BAT). After obtaining informed consent and all initial screening visit procedures, patients will participate in two four-hour recording sessions in the whole room indirect calorimeter to assess resting energy expenditure, and patient's thermal (comfort) response to the temperature of the room. |
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| Brown Adipose Tissue Negative Patients | Patients with known malignancy and no evidence of brown adipose tissue BAT activity positron emission tomography/ computerized tomography (PET/CT) scans to be matched to group 1 for primary tumor and stage, sex, age (±5 years), BMI (±3 Kg/m2). After obtaining informed consent and all initial screening visit procedures, patients will participate in two four-hour recording sessions in the whole room indirect calorimeter to assess resting energy expenditure, and patient's thermal (comfort) response to the temperature of the room. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resting Energy Expenditure | Procedure | During each visit, the participant will be assessed in a resting state in a stable temperature controlled environment, and will undergo tests to find out how the body adjusts its metabolism to different temperatures. |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in resting energy expenditure between brown adipose tissue (BAT)-positive and BAT-negative patients with cancer. | Characterization of the energy metabolism profiles of cancer patients with and without evidence of BAT activation will be assessed utilizing one sided t-test. | 27 Months |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in energy expenditure between room temperature and response to warm exposure (energy expenditure) in BAT-positive and BAT-negative cancer patients. | Assessment of environmental modulation as an effective strategy to mitigate maladaptive BAT activation in patients with malignancy will be assessed by two-sided t-test. | 27 Months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients equal to or greater than forty years of age with an active cancer diagnosis.
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| Name | Affiliation | Role |
|---|---|---|
| Francesco S Celi, MD, MHSc | Virginia Commonwealth University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Virginia Commonwealth University/ Massey Cancer Center | Richmond | Virginia | 23298-0070 | United States |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D004734 | Energy Metabolism |
| ID | Term |
|---|---|
| D008660 | Metabolism |
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| Thermal Comfort Questionnaire | Other | Patients will be given a questionnaire to assess their thermal response (whether they felt warmer or colder) during each study visit. |
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