Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery

Interest of the Nefopam and PCA Morphine Combination for Postoperative Analgesia in Patients Undergoing Colon Surgery

This study analyses interest of iv nefopam in combination with paracetamol after major abdominal surgery because the effect of morphine-sparing is discussed when combined these agents.

Inclusion Criteria:

• Adult patient with a score ASA between I and III
• Patient scheduled for elective major abdominal surgery (by laparotomy) for cancer or diverticulosis
• Patient that signed the consent form

Exclusion Criteria:

• - Patient treated in emergency situation
• Patient with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis)
• Patient that needs a surgery for restoration of continuity
• Patient pregnant, breastfeeding, or during periods of genital activity using no contraception.
• Patient with contraindications to nefopam, morphine, or paracetamol
• Patient with chronic obstructive pulmonary disease, renal or severe hepatic impairment
• Patient under analgesics treatment
• Patient who participated in a clinical study in the previous 6 months.