This study analyses interest of iv nefopam in combination with paracetamol after major abdominal surgery because the effect of morphine-sparing is discussed when combined these agents.

Inclusion Criteria:

• Adult patient with a score ASA between I and III
• Patient scheduled for elective major abdominal surgery (by laparotomy) for cancer or diverticulosis
• Patient that signed the consent form

Exclusion Criteria:

• - Patient treated in emergency situation
• Patient with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis)
• Patient that needs a surgery for restoration of continuity
• Patient pregnant, breastfeeding, or during periods of genital activity using no contraception.
• Patient with contraindications to nefopam, morphine, or paracetamol
• Patient with chronic obstructive pulmonary disease, renal or severe hepatic impairment
• Patient under analgesics treatment
• Patient who participated in a clinical study in the previous 6 months.