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This study was performed to determine the prognosis of patients after cardiac arrest using serum markers called NGAL. The initial NGAL values of patients with post-cardiac arrest syndrome are checked by blood tests, and the long-term neurological prognosis and survival rate are collected after 6 months.
Serum NGAL is currently being used as a test to determine the likelihood of developing renal failure. However, in a previous study, serum NGAL correlated with neurological prognosis in post cardiac arrest syndrome patients. This prospective study attempts to see the role of serum NGAL as a prognostic factor by including a sufficient number of patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| good neurologic outcome | Patients with good neurological prognosis after 6 months (CPC 1, 2). serum NGAL is collected. |
| |
| poor neurologic outcome | Patients with poor neurological prognosis after 6 months (CPC 3, 4, 5). serum NGAL is collected. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| serum NGAL | Diagnostic Test | serum NGAL was measured at 0, 24, 48, and 72 hours after recovery of spontaneous circulation. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Long term neurologic outcome | Patients' CPC score after 6 months (good outcome : CPC score 1, 2 / poor outcome : CPC score 3, 4, 5) | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of participants with Overall Survival at 6 months | 6-month survival rate of patients' | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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Adult survivors after out-of-hopital cardiac arrest who underwent targeted temperature management and survived longer than 3 days.
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| Name | Affiliation | Role |
|---|---|---|
| Joo Suk Oh, MD PhD | The Catholic University of Korea, Uijeongbu St. Mary's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uijeongbu St. Mary's Hospital | Uijeongbu-si | Gyeonggi-do | 11765 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26457752 | Background | Elmer J, Jeong K, Abebe KZ, Guyette FX, Murugan R, Callaway CW, Rittenberger JC; Pittsburgh Post-Cardiac Arrest Service. Serum Neutrophil Gelatinase-Associated Lipocalin Predicts Survival After Resuscitation From Cardiac Arrest. Crit Care Med. 2016 Jan;44(1):111-9. doi: 10.1097/CCM.0000000000001357. | |
| 29317152 | Result |
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| ID | Term |
|---|---|
| D058687 | Out-of-Hospital Cardiac Arrest |
| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Serum
| Park YR, Oh JS, Jeong H, Park J, Oh YM, Choi S, Choi KH. Predicting long-term outcomes after cardiac arrest by using serum neutrophil gelatinase-associated lipocalin. Am J Emerg Med. 2018 Apr;36(4):660-664. doi: 10.1016/j.ajem.2017.12.013. Epub 2017 Dec 7. |