Biomarker Study for Prediction of aGVHD

Biomarker Identification for aGVHD After Allogeneic Stem Cell Transplantation: a Multiple Center Study

This is a prospective study in patients receiving allogeneic stem cell transplantation. The blood samples on Day-14, -7, 0 and every 7 days until D100 were collected together with clinical data. In the final analysis, cytokines and biomarkers analysis will be carried out and compared between patients in No aGVHD and grade II-IV aGVHD.

This is a prospective study, observation study in patients receiving allogeneic stem cell transplantation in 4 BMT centers in Shanghai. The blood samples (on Day-14, -7, 0 and every 7 days until D100) and clinical data will be collected. In the final analysis, a panel of cytokines and biomarkers analysis of serial blood samples will be carried out and compared between patients with no aGVHD and grade II-IV aGVHD.

Inclusion Criteria:

• all patients undergoing allogeneic stem cel transplantation
• with informed consent
• patients survived without aGVHD or relapse and patients with development of grade II-IV aGVHD

Exclusion Criteria:

• patients with blood sample and clinical data not available