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Observe the effect os radiotherapy plus or not plus endostar in the treatment of brain metastasis in NSCLC
The investigators will observe the time controlled by the brain lesion after the test and the total survival time of the patients. Meanwhile, during each follow-up, the investigators will extract cerebrospinal fluid for genomic analysis of cerebrospinal fluid
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| arm a | Placebo Comparator | This group is a placebo control group, and we will use radiation therapy plus Placebos as the control group for the study |
|
| arm b | Experimental | This group belongs to the experimental group. We will use radiotherapy combined with endostar for treatment, so as to judge the efficacy of the medicine |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| endostar | Drug | endostatin |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Progression Free Survival (PFS) | the time from the start of treatment to the progression of the brain metastases, in months | From date of randomization until the date of first documented progression of brain lesions, and the maximum evaluation time is 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Overall survival （OS） | the total survival time of the patient from the start of treatment | From date of randomization until the date of death, assessed up to 36 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| dong xiaorong, Dr | Contact | 15071116896 | zrg27@163.com |
| Name | Affiliation | Role |
|---|---|---|
| dong xiaorong, Dr | china goverment | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Union Hospital | Recruiting | Wuhan | Hubei | 430000 | China |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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| ID | Term |
|---|---|
| C522911 | endostar protein |
| D011878 | Radiotherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| Placebos | Drug | saline solution |
|
|
| radiotherapy | Radiation | radiotherapy |
|
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |