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To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.
Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined.
Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tetracycline | Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation |
| |
| Dexamethasone | Teeth were soaked in dexamethasone (60μ ml-1) for 20 minutes before replantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tetracycline | Procedure | Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of teeth with periodontal regeneration | Periodontal regeneration was assessed with periodontal examination, percussion, Periotest measurements and periapical radiograph. | After a mean observation period of 12.9±2.4 years (one visit only) |
| Number of teeth with pulpal regeneration | Pulpal regeneration was assessed with periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow and periapical radiograph. | After a mean observation period of 12.9±2.4 years (one visit only) |
| Measure | Description | Time Frame |
|---|---|---|
| Number of teeth that survived | Assessed by visual inspection | After a mean observation period of 12.9±2.4 years (one visit only) |
| Number of teeth with open versus closed apex at accident | Assessed by x-ray |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with avulsed permanent teeth who were treated between 2000-2008 at the Department of Oral Surgery, zmk Bern
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| Name | Affiliation | Role |
|---|---|---|
| Vivianne Chappuis, PD Dr. | Department of Oral Surgery and Stomatology, zmk Bern, University Bern | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| zmk Bern | Bern | 3010 | Switzerland |
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| Dexamethasone | Procedure | Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation |
|
| At baseline |
| Patients satisfaction | Measured by OHIP-14 score | After a mean observation period of 12.9±2.4 years (one visit only) |
| ID | Term |
|---|---|
| D000071562 | Fractures, Avulsion |
| ID | Term |
|---|---|
| D050723 | Fractures, Bone |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D013752 | Tetracycline |
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D013754 | Tetracyclines |
| D009279 | Naphthacenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D011083 | Polycyclic Compounds |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D013259 | Steroids, Fluorinated |
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