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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A03327-46 | Other Identifier | ID-RCB |
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Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in clinical practice. This arrhythmia is responsible for 15% of strokes and more than 30% of strokes on people over 65 years.
According to studies, 30 to 40% of isolated atrial fibrillations could be familial. Atrial fibrillation has significant genetic heterogeneity. About 40 genes have been identified as potentially involved. Studies have identified genes common to the risk of atrial fibrillation and stroke. Despite the pathophysiology of atrial fibrillation has been intensively and extensively studied for almost a century, there are still many questions. The pathophysiology is not sufficiently understood to allow finding more effective therapies. It is necessary to identify genetic determinants and thus potentially new pharmacological targets more adapted.
The establishment of a biological database will test hypotheses concerning the genetic origin and thromboembolic process of atrial fibrillation and associated stroke.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1a | Patient with atrial fibrillation and without stroke history. |
| |
| Group 1b | Patient with atrial fibrillation with scheduled electrophysiology exploration or ablation. |
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| Group 1c | Patient with atrial fibrillation and with stroke history. |
| |
| Group 2 | Patients aged over 80 years old and without history of atrial fibrillation. |
| |
| Group 3 | Patient with cryptogenic stroke or transient ischemic attack history before the age of 50. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood taken | Biological | Collection of clinical data |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quality of DNA sample | Quality is based on the measure of the purity of DNA with absorbance assay at 260/280nm on a spectrophotometer. For Plasma sample, purity is based on absence of hemolyzed blood by visual observation. | 1 day (the day of the storage) |
| Quality of Plasma sample | Quality is based on the purity of Plasma sample that is based on absence of hemolyzed blood by visual observation. | 1 day (the day of the storage) |
| Quality of preservation of the sample | The quality of preservation of the sample throughout the conservation duration is based on the number of freezing/thawing of each cryotube that will be notified. As weel as any interruption in the freezing process (power failure, freezer failure). | 7 years (during all the duration of the collection) |
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Group 1a
Inclusion Criteria :
- AF history
Exclusion Criteria :
Group 1b
Inclusion Criteria :
Exclusion Criteria :
Group 1c
Inclusion Criteria :
Exclusion Criteria :
Group 2
Inclusion Criteria :
Exclusion Criteria :
Group 3
Inclusion Criteria :
Exclusion Criteria :
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Atrial fibrillation patient Stroke patient Patient over 80
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philippe CHEVALIER, PU-PH | Contact | 04 72 35 70 27 | +33 | philippe.chevalier@chu-lyon.fr |
| Elodie MOREL | Contact | 04 72 35 73 81 | +33 | elodie.morel01@chu-lyon.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service neurologie Centre hospitalier Fleyriat | Recruiting | Bourg-en-Bresse | 01000 | France |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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DNA, plasma
| Blood taken | Genetic | Collection of DNA |
|
| Blood taken | Genetic | Collection of plasma |
|
| Service d'urgences Neurovasculaires - service de neurologie vasculaire , Hôpital Pierre Wertheimer | Recruiting | Bron | 69677 | France |
|
| Service de rythmologie, hôpital cardiologique Louis Pradel | Recruiting | Bron | 69677 | France |
|
| Service de médecine gériatrique Centre hospitalier Lyon Sud, Groupement hospitalier Sud | Recruiting | Pierre-Bénite | 69495 | France |
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| Hôpital des charpennes | Recruiting | Villeurbanne | 69100 | France |
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| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |