patient will receive topical application of latanoprost 0.005% eye drops solution twice daily for 3 months preceded by microneeding in sessions by dermapen every 2 weeks for 3 months (totally 6 sessions).

Patient will receive topical application of latanoprost 0.005% eye drops solution only twice daily for 3 months (active control side).

Topical application of latanoprost 0.005% eye drops solution only twice daily for 3 months.

• To apply latanoprost solution, one drop of the solution will be distributed over 1cm2 of depigmented skin. Side effects will be recorded.

VASI score: The percentage of vitiligo involvement is calculated in terms of hand units. One hand unit is approximately equivalent to 1% of the total body surface area. The degree of pigmentation is estimated to the nearest of one of the following percentages:

• 100% - complete depigmentation, no pigment is present
• 90% - specks of pigment present
• 75% - depigmented area exceeds the pigmented area
• 50% - pigmented and depigmented areas are equal
• 25% - pigmented area exceeds depigmented area
• 10% - only specks of depigmentation present. The VASI for each body region is determined by the product of the area of vitiligo in hand units and the extent of depigmentation within each hand unit measured patch.

Total body VASI = S All body sites [Hand Units] x [Residual depigmentation]. (Feily et al., 2014).