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This is a descriptive observational study, in which data are collected in an epidemiological fashion. This study does not intend to alter or intervene the current medical practice of the recruited patients. Data will be collected in prospective manner.
This is a descriptive observational study, in which data are collected in an epidemiological fashion. This study does not intend to alter or intervene the current medical practice of the recruited patients. Data will be collected in prospective manner.
The eligible patients will be recruited after NGS analysis for tumor tissue and the inform-consent is obtained. The study required information will be collected (every 3 months).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No treatment is included in this protocol. | Other | No drug intervention or tissue sampling will be included in this study. |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical relevance between genomic profiling and overall survival | Kaplan-meier analysis of overall survival based on different genetic alteration | [ Time Frame: From registration onto that step until death, or censored at the date of last contact, assessed up to 3 years] |
| Measure | Description | Time Frame |
|---|---|---|
| The characteristics of genomic variation and dynamic changes during different anti-tumor treatment | Subtypes, incidence and dynamic changes of genomic variants during treatment process. | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
None.
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Histologically or cytologically confirmed NSCLC
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yi-Long Wu, Professor | Contact | +86 20 83827812 | syylwu@live.cn | |
| Xiao-Yan Bai, Dr. | Contact | +8615347435499 | 799836599@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Yi-Long Wu, Professor | Guangdong Association of Clinical Trials (GACT) | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology | Recruiting | Guangzhou | Guangdong | 510080 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37488286 | Derived | Liu SM, Tu HY, Wei XW, Yan HH, Dong XR, Cui JW, Zhou Z, Xu CR, Zheng MY, Li YS, Wang Z, Bai XY, Li AN, Sun YL, Huang J, Lin JX, Ke EE, Xu BF, Lu C, Du Y, Chen Y, Ma R, Wang BH, Cang SD, Wang BC, Chen HJ, Yang JJ, Li Y, Zhou Q, Wu YL. First-line pyrotinib in advanced HER2-mutant non-small-cell lung cancer: a patient-centric phase 2 trial. Nat Med. 2023 Aug;29(8):2079-2086. doi: 10.1038/s41591-023-02461-x. Epub 2023 Jul 24. | |
| 35659479 |
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| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
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|
| Derived |
| Liu SM, Yan HH, Wei XW, Lu C, Dong XR, Du Y, Cui JW, Chen Y, Ma R, Wang BH, Zhou Z, Cang SD, Yang JJ, Tu HY, Zhang XC, Zhong WZ, Zhou Q, Wu YL. Biomarker-Driven Studies With Multi-targets and Multi-drugs by Next-Generation Sequencing for Patients With Non-Small-Cell Lung Cancer: An Open-Label, Multi-center, Phase II Adaptive Umbrella Trial and a Real-World Observational Study (CTONG1702&CTONG1705). Clin Lung Cancer. 2022 Nov;23(7):e395-e399. doi: 10.1016/j.cllc.2022.05.009. Epub 2022 May 11. |
| D013899 |
| Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |