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| ID | Type | Description | Link |
|---|---|---|---|
| 2018-A00653-52 | Other Identifier | IdRCB | |
| 2018.05.02 | Other Identifier | CPP |
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During the past three decades, researchers have paid particular attention to the study of olfactory disorders in depression. Recent studies have shown that depression is characterized by a change in olfactory and emotional perception resulting in a decrease of the perception of positive stimuli (odors and facial expressions) and an increase in perception of negative stimuli (odors). Moreover, it has also been shown in healthy subjects that the presence of minor depressive symptoms leads to a decreasing of olfactory sensitivity. However, odor discrimination was not impaired in these subjects. This observation suggest the presence of a change in "targeted" olfactory perception in people with depressive symptoms without reporting major depression. In addition, studies in subjects with olfactory disorders (following respiratory tract infections or following Parkinson's disease) have shown an improvement in olfactory function after daily training with odors during 12 weeks.
From all these observations, the hypothesis is that an olfactory training could improve the overall olfactory functioning and the emotional perception of the subjects presenting minor depressive symptoms and of the depressed patients.
Recent studies have shown that depression is characterized by a change in olfactory and emotional perception resulting in a decrease of the perception of positive stimuli (odors and facial expressions) and an increase in perception of negative stimuli (odors). Moreover, it has also been shown in healthy subjects that the presence of minor depressive symptoms leads to a decreasing of olfactory sensitivity. However, odor discrimination was not impaired in these subjects. This observation suggest the presence of a change in "targeted" olfactory perception in people with depressive symptoms without reporting major depression. In addition, studies in subjects with olfactory disorders (following respiratory tract infections or following Parkinson's disease) have shown an improvement in olfactory function after daily training with odors during 12 weeks. Therefore, the hypothesis is that an olfactory training could improve the overall olfactory functioning and the emotional perception of the subjects presenting minor depressive symptoms and of the depressed patients.
The main objective is to study the effect of daily olfactory training on the emotional state and emotional perception of the subject. The effect of the training will be evaluated using three types of evaluations: (1) a clinical evaluation and the psychometric scales, (2) the investigation of the olfactory function and (3) the study of the emotional perception.
The secondary objectives are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sensory training | Other | Sensory (Olfactory or visual) training will be done at home for 12 weeks. The effect of the training will be evaluated using an experimental protocol includes (i) clinical and psychometric evaluations, (ii) the study of olfactory perception using Sniffin' Sticks Test and (iii) the study of the emotional perception using the "subjective" Sense'n Feel method and the "objective" measurement of the spontaneous pupillary dilatation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sensory training | Other | 12 weeks sensory training |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline Olfactory Perception at 3 months | Score obtained with the Sniffin 'Stick test | Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Measure | Description | Time Frame |
|---|---|---|
| Emotional perception measured Sense'n Feel Method | Score obtained with Sense'n Feel Method | Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Emotional perception measured with SMI RED-m Scientific device |
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Inclusion Criteria healthy subjects:
Inclusion Criteria depressed patients:
Exclusion Criteria healthy subjects and depressed patients:
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| Name | Affiliation | Role |
|---|---|---|
| Wissam EL-HAGE, MD-PhD | University Hospital, Tours | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University health service, University ,Tours | Tours | 37000 | France | |||
| UMR 1253 IBrain, University, Tours |
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| ID | Term |
|---|---|
| D003863 | Depression |
| D003865 | Depressive Disorder, Major |
| D000086582 | Anosmia |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D003866 | Depressive Disorder |
| D019964 | Mood Disorders |
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| ID | Term |
|---|---|
| D012903 | Smell |
| ID | Term |
|---|---|
| D012677 | Sensation |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Observation of spontaneous pupillary dilatation with SMI RED-m Scientific device
| Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Psychometric scale MINI : Psychiatric disorders exploration | Mini International Neuropsychiatric Interview | Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Psychometric scale TAS-20 : alexithymia assessment | Twenty-item toronto Alexithymia Scale (TAS-20) | Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Psychometric scale STAI-Y : anxiety assessment | State Trait Anxiety Inventory | Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Psychometric scale SHAPS : anhedonia assessment | The Snaith-Hamilton Pleasure Scale | Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Psychometric scale QIDS-SR16 : Depression assessment | Quick Inventory of Depressive Symptomatology | Baseline (T0), a month and a half (T1.5), 3 months (T3) |
| Tours |
| 37032 |
| France |
| University Psychiatric Clinic, University hospital,Tours | Tours | 37044 | France |
| D001523 |
| Mental Disorders |
| D000857 | Olfaction Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |