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The purpose of this study is to explore the perinatal risk factors of preterm birth in China.
Preterm birth is a global scourge, and the leading cause of newborn deaths (babies in the first 4 weeks of life) and raised to the leading cause of death among children under 5 years of age, responsible for approximately 1 million deaths in 2015. In China, the prevalence of preterm increased from 4~5% in 1990s to 7~10% in 2010. Preterm birth become a burden to both the family and society. Therefore, the risk factors of preterm birth become the critical issue of both Obstetrics and Neonatology. More importantly, few multicenter prospective studies on risk factors of preterm birth included potential reasons such as maternal occupation, psychology condition and lifestyles during pregnancy were conducted in China. Thus, the aim of our study is to explore the perinatal risk factors of preterm birth nowadays in China.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm group | All the live-born infants with gestational age less than 37weeks and more than 20weeks born in the cooperative hospital every day or every two or three days. | ||
| Term group | The one next-live-born infants with gestational age at 37weeks or more than 37weeks. |
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| Measure | Description | Time Frame |
|---|---|---|
| live-born preterm | less than 37weeks gestational age | at birth |
| Measure | Description | Time Frame |
|---|---|---|
| birth weight (g) | Infant's weight recorded at the time of birth | at birth |
| gestation age (week) | the number of completed weeks of gestation, which was determined by the duration of menorrhoea or confirmed by an early ultrasound scan during pregnancy |
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Inclusion Criteria:
Exclusion Criteria:
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Live-born preterm infants and one term infants born following the preterm infants in the same cooperation hospitals
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| Name | Affiliation | Role |
|---|---|---|
| Chen Chao, PhD, MD | Children's Hospital of Fudan University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xiamen Maternal and Child Health Care Hospital | Xiamen | Fujian | 361000 | China | ||
| The Second Affiliated Hospital of Guangzhou Medical University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27839855 | Background | Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, Lawn JE, Cousens S, Mathers C, Black RE. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2016 Dec 17;388(10063):3027-3035. doi: 10.1016/S0140-6736(16)31593-8. Epub 2016 Nov 11. | |
| 22682464 |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| at birth |
| Apgar score | determined by evaluating the newborn baby on five simple criteria（Appearance, Pulse, Grimace, Activity, Respiration） on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. | 1min after birth |
| Apgar score | determined by evaluating the newborn baby on five simple criteria（Appearance, Pulse, Grimace, Activity, Respiration） on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. | 5min after birth |
| small for gestational age | a birth weight below the 10th percentile for the gestational age | at birth |
| Guangzhou |
| Guangdong |
| 510260 |
| China |
| The Maternal and Child Health Hospital of Hainan Province | Haikou | Hainan | 570206 | China |
| The First Affiliated Hospital of Zhengzhou University | Zhengzhou | Henan | 450052 | China |
| Changzhou Maternal and Child Health Care Hospital | Changzhou | Jiangsu | 213003 | China |
| Jiangsu Province Hospital | Nanjing | Jiangsu | 210029 | China |
| Tongxin County People's Hospital | Wuzhong | Ningxia | 751300 | China |
| The First People's Hospital of Yinchuan | Yingchuan | Ningxia | 750001 | China |
| Binzhou Medical University Hospital | Binzhou | Shandong | 256603 | China |
| Jining NO.1 People's Hospital | Jining | Shandong | 272011 | China |
| Affiliated Hospital of Qingdao University | Qingdao | Shandong | 266003 | China |
| Qingdao Jimo People's Hospital | Qingdao | Shandong | 266200 | China |
| Obstetrics and Gynecology Hospital of Fudan University | Shanghai | Shanghai Municipality | 200011 | China |
| Songjiang Maternity & Child Health Hospital of Shanghai | Shanghai | Shanghai Municipality | 201620 | China |
| Yueqing Hospital Affiliated to Wenzhou Medical University | Wenzhou | Zhejiang | 325600 | China |
| Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Vera Garcia C, Rohde S, Say L, Lawn JE. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012 Jun 9;379(9832):2162-72. doi: 10.1016/S0140-6736(12)60820-4. |
| D000091642 | Urogenital Diseases |