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The aim of this study is to evaluate the effects of magnesium sulfate as an adjuvant to bupivacaine in suprascapular nerve block on the duration and quality of postoperative analgesia following shoulder arthroscopy, postoperative pain VAS scores, intraoperative fentanyl requirements, sedation scores, respiratory depression, postoperative 24 hours cumulative morphine consumption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bupivacaine | Experimental | Ultrasound-guided suprascapular nerve block using bupivacaine will be performed before induction of general anesthesia |
|
| Bupivacaine-magnesium | Active Comparator | Ultrasound-guided suprascapular nerve block using bupivacaine in conjunction of magnesium sulfate will be performed before induction of general anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bupivacaine | Drug | Ultrasound-guided suprascapular nerve block will be performed using 7 mL of 0.5% bupivacaine plus 3 mL of 0.9% saline |
|
| Measure | Description | Time Frame |
|---|---|---|
| Duration of postoperative analgesia | time from administering the study solution in the suprascapular block till the time for the first rescue morphine request | For 8 hours after suprascapular nerve block |
| Measure | Description | Time Frame |
|---|---|---|
| Pain score at rest | Pain score as assessed using visual analogue scale to assess the severity of postoperative pain (0 mm for no pain and 100 mm for worst imaginable pain) | time 0 (after extubating) and at 30 minutes, 1 hour , 2 hours, 4hours, 6hours, 8hours,12 hours , 16hours, 20 hours and 24 hours postoperatively |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hanaa M Elbendary, MD | Contact | 00201005781768 | hanaa_elbendary@yahoo.com | |
| Samah El Kenany, MD | Contact | 00201002262557 | sk_20022000@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Hanaa M Elbendary, MD | Assistant Professor, MD anesthesia Department, Faculty of Medicine, Mansoura University, Egypt | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mansoura University | Al Mansurah | DK | 050 | Egypt |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D015742 | Propofol |
| D014463 | Ultrasonography |
| D000077149 | Sevoflurane |
| D000077123 | Rocuronium |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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Double-blind study
| Bupivacaine-magnesium | Drug | Ultrasound-guided suprascapular nerve block will be performed using 7 mL of 0.5% bupivacaine plus magnesium sulfate 10% (3 ml) (total 10mL) |
|
| Propofol | Drug | Using propofol 1.5-2.5 mg/kg |
|
| Ultrasound | Device | Ultrasound-guided suprascapular nerve block |
|
| Sevoflurane | Drug | Sevoflurane 0.7-1.5 MAC in 40% oxygen |
|
| Rocuronium | Drug | Rocuronium 0.6 mg/kg |
|
| Pain score on shoulder abduction |
Pain score as assessed using visual analogue scale to assess the severity of postoperative pain (0 mm for no pain and 100 mm for worst imaginable pain) |
| time 0 (after extubating) and at 30 minutes, 1 hour , 2 hours, 4hours, 6hours, 8hours,12 hours , 16hours, 20 hours and 24 hours postoperatively |
| Systolic arterial blood pressure | At baseline, immediately after induction of anaesthesia, at skin incision, every 15 minutes till the end of surgery, on arrival to PACU, then at 30, 60 minutes after surgery , every 6 hours up to 24 hours postoperatively |
| Diastolic arterial blood pressure | At baseline, immediately after induction of anaesthesia, at skin incision, every 15 minutes till the end of surgery, on arrival to PACU, then at 30, 60 minutes after surgery , every 6 hours up to 24 hours postoperatively |
| Heart rate | At baseline, immediately after induction of anaesthesia, at skin incision, every 15 minutes till the end of surgery, on arrival to PACU, then at 30, 60 minutes after surgery ,every 6 hours up to 24 hours postoperatively |
| Intraoperative fentanyl requirements | For 5 hours after suprascapular nerve block |
| Sedation scores | Sedation: will be assessed using a sedation scale (awake and alert= 0; quietly awake= 1; asleep but easily roused= 2; deep asleep= 3). | at 1 hour, 2 hours, and 6 hours postoperatively |
| The degree of nausea and vomiting | Nausea will be measured using a numerical rating system (none= 0; mild= 1; moderate= 2; severe= 3) | For 24 hours after surgery |
| Number of vomiting episodes | For 24 hours after surgery |
| Number of antiemetics received | For 24 hours after surgery |
| Postoperative cumulative morphine consumption | For 24 hours after surgery |
| D000588 |
| Amines |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |