Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma

Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma

Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This retrospective multicentric study aimed to predict the prognosis of patients with complete pathological response after neoadjuvant treatment.

Inclusion Criteria

• patients with a histologically proven low rectal adenocarcinoma,
• no previous or synchronous colorectal disease,
• UICC stage I-III patients who underwent neoadjuvant chemoradiotherapy or chemotherapy,
• followed by total mesorectal excision (TME), and
• a complete pathological response defined as ypT0N0

Exclusion Criteria:

- all patients with metastatic tumors or missing data