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Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This retrospective multicentric study aimed to predict the prognosis of patients with complete pathological response after neoadjuvant treatment.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rectal resection | Procedure | total mesorectal excision |
| Measure | Description | Time Frame |
|---|---|---|
| Local recurrence rate | A postoperative local recurrence was defined by biopsy-proven or radiographic evidence of local recurrent disease. | From date of surgery until the date of first documented local progression assessed up to 100 months |
| Distant recurrence rate | A postoperative distant recurrence was defined by biopsy-proven or radiographic evidence of distant recurrent disease. | From date of surgery until the date of first documented distant progression assessed up to 100 months |
| Measure | Description | Time Frame |
|---|---|---|
| Predictive factors of disease free survival | Disease free survival was defined as the period between the day of surgery and the date of recurrence or the last date of follow-up | From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months |
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Inclusion Criteria
Exclusion Criteria:
- all patients with metastatic tumors or missing data
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All consecutive patients who underwent neoadjuvant treatment followed by total mesorectal excision for rectal adenocarcinoma in 8 centers
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Batna anticancer center | Algiers | Algeria | ||||
| Mohammed V University Medical School, Surgery Department, Military Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31660903 | Derived | Souadka A, Majbar MA, Benkabbou A, Serji B, Souiki T, Bouchentouf SM, Abid M, El Khannousi B, El Harroudi T, El Malki HO, Raiss M, Ifrine L, Mazaz K, Zentar A, Mohsine R, Souadka A, Belkouchi A, Ahallat M, Hrora A; Moroccan Society of Surgery. Predictive factors of disease-free survival after complete pathological response to neoadjuvant radiotherapy for rectal adenocarcinoma: retrospective case series. BMC Cancer. 2019 Oct 28;19(1):1008. doi: 10.1186/s12885-019-6239-3. |
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| Rabat |
| Please Enter the State Or Province |
| 10001 |
| Morocco |
| Mohammed V University Medical School, Surgical Department "A", Ibn Sina Hospital | Rabat | Please Enter the State Or Province | 10001 | Morocco |
| Mohammed V University Medical School, Surgical Department "C", Ibn Sina Hospital, | Rabat | Please Enter the State Or Province | 10001 | Morocco |
| National Institut of Oncology, Surgical oncology department | Rabat | Please Enter the State Or Province | 10001 | Morocco |
| Sidi Mohammed Ben Abdellah University Medical School, Surgery Department, | Fes | Morocco |
| Mohammed Ist University Medical School, Surgical Oncology, Hospital el Farabi | Oujda | Morocco |
| Private surgical oncology center | Salé | Morocco |
| ID | Term |
|---|---|
| D012004 | Rectal Neoplasms |
| D000095384 | Pathologic Complete Response |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D018450 | Disease Progression |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000078542 | Proctectomy |
| ID | Term |
|---|---|
| D000099090 | Surgical Procedures, Colorectal |
| D013505 | Digestive System Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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