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| Name | Class |
|---|---|
| DuPont Nutrition and Health | INDUSTRY |
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The purpose of this study is to investigate the cognitive and mood effects of a probiotic dietary supplement when taken daily for 42 days in healthy older adults aged 65+
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lactobacillus paracasei Lpc-37 | Active Comparator | Probiotic |
|
| Placebo | Placebo Comparator | Inert placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lactobacillus paracasei Lpc-37 | Dietary Supplement | Live probiotic bacteria |
|
| Measure | Description | Time Frame |
|---|---|---|
| Episodic memory score | This is a composite measure derived from summing the z score performance on the following cognitive tasks: immediate word recall, delayed word recall, delayed picture recognition, delayed word recognition (-4 to 4) | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| STAI-state total score | State-trait anxiety inventory 'state' total score (20-80) | 6 weeks |
| STAI-trait total score | State-trait anxiety inventory 'trait' total score (20-80) |
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Inclusion Criteria:
Exclusion criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philippa A Jackson, PhD | Northumbria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumbria University | Newcastle upon Tyne | Tyne and Wear | NE1 8ST | United Kingdom |
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| Label | URL |
|---|---|
| Link to study site website | View source |
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| Placebo | Dietary Supplement | Inert placebo matched for taste and appearance |
|
| 6 weeks |
| Accuracy of attention score | This is a composite measure derived from summing the z score accuracy performance on the choice reaction time and Rapid visual information processing tasks (-2 to 2) | 6 weeks |
| Speed of attention score | This is a composite measure derived from summing the z score reaction times from the choice reaction time and Rapid visual information processing task (-2 to 2) | 6 weeks |
| Working memory score | This is a composite measure derived from summing the z score accuracy performance on the numeric working memory task and Corsi block-tapping task (-2 to 2) | 6 weeks |
| Speed of memory score | This is a composite measure derived from summing the z score reaction times on the numeric working memory task, the delayed name / face recall task, the delayed picture recognition task and the delayed word recognition task (-4 to 4) | 6 weeks |
| Delayed word recall correct | total number of correctly identified words (0-15) | 6 weeks |
| Delayed word recall errors | total number of error responses | 6 weeks |
| Picture recognition reaction time | (ms) | 6 weeks |
| Picture recognition accuracy | 6 weeks |
| Word recognition reaction time | (ms) | 6 weeks |
| Word recognition accuracy | 6 weeks |
| Name to Face Recall correct responses | number | 6 weeks |
| Name to Face Recall reaction time | (ms) | 6 weeks |
| Peg and Ball task Planning time | (ms) | 6 weeks |
| Peg and Ball task Completion time | (ms) | 6 weeks |
| Peg and Ball task errors | Number | 6 weeks |
| Stroop task accuracy | 6 weeks |
| Stroop task reaction time | (ms) | 6 weeks |
| Immediate word recall task correctly identified words | total number (0-15) | 6 weeks |
| Immediate word recall task error responses | total number | 6 weeks |
| Numeric working memory accuracy | 6 weeks |
| Numeric working memory reaction time | (ms) | 6 weeks |
| Choice reaction time accuracy | 6 weeks |
| Choice reaction time reaction time | (ms) | 6 weeks |
| Rapid visual information processing accuracy | 6 weeks |
| Rapid visual information processing reaction time | (ms) | 6 weeks |
| Rapid visual information processing false alarms | number | 6 weeks |
| Corsi blocks accuracy | Average scores from the last five correctly completed trials from the Corsi block-tapping task | 6 weeks |
| Rapid visual information processing accuracy | (%) - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Rapid visual information processing reaction time | (ms) - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Rapid visual information processing false alarms | number - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Serial 3 subtractions total responses | number- calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Serial 3 subtractions total error responses | number - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Serial 7 subtractions total responses | number - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Serial 7 subtractions total error responses | number - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Mental fatigue | visual analogue scale (%) - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Alertness | visual analogue scale (%) - calculated from the 3 cycles of the Cognitive Demand Battery | 6 weeks |
| Alert | derived from Bond Lader visual analogue scale | 6 weeks |
| Content | derived from Bond Lader visual analogue scale | 6 weeks |
| Calm | derived from Bond Lader visual analogue scale | 6 weeks |