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| Name | Class |
|---|---|
| Society for Endocrinology | OTHER |
| Royal Liverpool University Hospital | OTHER_GOV |
| University of Birmingham | OTHER |
| University of Exeter |
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There is clear evidence that regular exercise improves wellbeing and reduces the risk of diabetes related complications in people with type 1 diabetes. However, many people with type 1 diabetes do not exercise regularly. The primary reason for this is fear of hypoglycaemia and loss of glycaemic control associated with exercise. This loss of glycaemic control is associated with traditional moderate intensity continous aerobic exercise advocated in the guidelines for exercise in people with type 1 diabetes. Recent work (unpublished) from our lab suggests high intensity interval training (HIT) may reduce the risk of hypoglycaemia in people with type 1 diabetes, however stronger evidence is needed before firm conclusions can be drawn.
Therefore, the aim of this study is to determine the effects of HIT on glycaemic control in people with type 1 diabetes compared to no exercise and traditional moderate intensity continous exercise.
24 people with type 1 diabetes will be recruited to complete a randomised counterbalanced cross over study comparing 3x 2-week interventions periods. During these intervention periods participant will maintain their habitual lifestyle but complete either no exercise (control), traditional moderate intensity continous exercise or high intensity interval training. Throughout the intervention periods participants glycaemic control will be monitored using a flash glucose monitor.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | Participants will continue with their habitual lifestyle but perform no exercise for 2 weeks | |
| Moderate intensity continous training | Active Comparator | Participants will complete moderate intensity continous training during a 2 week intervention period |
|
| high intensity interval training | Experimental | Participants will complete high intensity interval training during a 2 week intervention period |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high intensity interval training | Behavioral | Participants will complete 6 sessions of high intensity interval training during a 2 week intervention period. The programme involves repeated 1 minute bouts of simple on the spot movements interspersed with 1 minute of rest. |
| Measure | Description | Time Frame |
|---|---|---|
| Severe hypoglycaemia | Number of severe hypoglycaemic events (<3mmol/l) during the 2 week intervention period | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Mean glucose | mean glucose level over 2 week recording period | 2 weeks |
| % of time in level 2 hypoglycaemia (<3.0mmol/L) | % of time in level 2 hypoglycaemia (<3.0mmol/L) over 2 week recording period |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Liverpool John Moores University | Liverpool | L33AF | United Kingdom |
No individual participant data will be shared outside the research team. Anonymised group data will be presented in research articles and presentations
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| ID | Term |
|---|---|
| D000072696 | High-Intensity Interval Training |
| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
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| OTHER |
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| moderate intensity continous training | Behavioral | Participants will complete 6 sessions of moderate intensity continous training during a 2 week intervention period. Participants will be asked to complete 30 minutes of continuous exercise. |
|
| 2 weeks |
| % of time in level 1 hypoglycaemia (3.0-3.9mmol/L) | % of time in level 1 hypoglycaemia (3.0-3.9mmol/L) over 2 week recording period | 2 weeks |
| % of time in target range (3.9-10.0mmol/L) | % of time in target range (3.9-10.0mmol/L) over 2 week recording period | 2 weeks |
| % of time in level 1 hyperglycaemia (10.0-13.9mmol/L) | % of time in level 1 hyperglycaemia (10.0-13.9mmol/L) over 2 week recording period | 2 weeks |
| % of time in level 2 hyperglycaemia (>13.9mmol/L) | % of time in level 2 hyperglycaemia (>13.9mmol/L) over 2 week recording period | 2 weeks |
| glycaemic variability (coefficient of variation and Standard Deviation) | glycaemic variability over 2 week recording period | 2 weeks |
| area under the curve of episodes of hypoglycaemia and hyperglycaemia | area under the curve of episodes of hypoglycaemia and hyperglycaemia 2 week recording period | 2 weeks |
| D009142 |
| Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |