Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children

Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children With Cochlear Implant Surgery

To investigate the effect of sevoflurane and propofol on the concentrations of serum homocysteine and folic acid in children who received cochlear implant surgery.

This study is a prospective single center, cross-reference clinical application study.This study plan to enroll 40 children with cochlear implant surgery. Children were selected randomly and divided into 2 groups.Each group has 20 patients. All children undergo orotracheal intubation, mechanical ventilation will given by anaesthetic machine (U.S. Ohmeda advance cs2 ) to maintain oxygen saturation above 95%, hemodynamics and other vital signs were monitored with the anesthesia monitor.In the operation room,2-3ml arterial blood will be taken.And the levels of homocysteine and folic acid will be measured at week 1.

Inclusion Criteria:

• children accepted cochlear implant surgery under general anesthesia
• no participate in any other trial up to 3 months before this study
• no acute infectious diseases, systemic diseases
• willing to participate in this study and sign the informed consent

Exclusion Criteria:

• unwilling to participate in this study
• with a history of serious liver or kidney dysfunction
• hemodynamic instability (etc. shock, blood pressure reduced by 30%)
• children with egg milk allergy
• children with a family history of malignant hyperthermia