The purpose of this proposed pilot study is to extend the KKC Heroes Circle program to people with opioid use disorder (OUD) who are currently enrolled in methadone maintenance treatment (MMT) and who wish to learn these techniques to reduce their behavioral and physiological dependence on medication.

The goal is to engage these MMT patients in a complementary (non-pharmacological) therapeutic activity that may improve their self-efficacy and personal control, reduce the impact of stressors and chronic pain, drug craving, affective and physical function, and lower reliance on pharmacological interventions.

Overall, this project will take approximately 1 year to complete, and will be divided into three phases (each about three months long).

Phase 1: The investigators will identify and consent 10 patients, regardless of age, sex, or race/ethnicity, enrolled at the Tolan Park Research Clinic who endorse a desire to lower their daily methadone maintenance dose but have been unable to do so.

Each participant will complete a 12-week protocol. There will be twice weekly visits (each ≈30 min total for all procedures) by the trained adult Kids Kicking Cancer (KKC) martial artists. Prior to receiving his/her methadone dose, the martial artist and patient will meet in a private area to promote attention and focus on the intervention, and for measurement of biomarker data. At baseline and during weeks 4, 8 and 12, the investigators will obtain pre- and post-session saliva samples (collected with a Salivette held under the tongue 3 min) to measure two stress biomarkers. The investigators will also measure heart rate and blood pressure. Each participant will receive 20 minutes of individual instruction in a therapeutic approach to lower their stress and life challenges. Each visit will include certain martial arts rituals, including the KKC "Power, Peace, Purpose"™ mantra, and Breath Brake®, introduced by videotapes made by the "heroes" (children). Other components of the intervention session, e.g. movement exercises and mental imagery, will be tailored to the patient, always ensuring that any physical maneuver is safe for that individual. They will also receive audio meditations for smart phones or, if unavailable, loaded onto mp3 players to practice the meditations.

At the beginning and end of each visit by the martial artist, the participant will use Visual Analog Scales (VAS, 0-10 range) to rate his/her momentary level of "pain", "drug craving", "anxiety", "anger", and "depression"; and he/she will complete the short form of the Positive and Negative Affect Schedule. Each meeting will be supplemented by phone calls 3 times a week from the martial artist to each patient to supply support.

Data collection measurements: Beck Depression Inventory-II, State-Trait Anxiety Inventory, Perceived Stress Scale, Difficulties with Emotion Regulation Scale, Coping Orientation to Problems Experienced (Brief-COPE), Alcohol and Drug Use Self-Efficacy Scale, Distress Tolerance Scale, Breath-hold Endurance task, Brief Pain Inventory, Medical Outcomes Study Short Form, a computerized measure of attentional function, the Attentional Network Task, also known as Flanker Task.

Methadone dose (baseline and weekly) and urine drug test results (baseline and twice weekly for these study participants) will be extracted from the patient's medical record, with the assistance of an authorized staff member.

Each Phase I participant will undergo non-Virtual Reality (VR) intervention procedures during weeks 1-6, and will then undergo VR-based intervention during weeks 7-12.

Phase 2 will extend phase 1 by evaluating a second group of 10 patients who will also participate over a 12-week period. Identical procedures to Phase 1 will be used; in addition, the investigators will include whole-brain fMRI (functional magnetic resonance imaging) scanning before and after completion of the full intervention. Patients will use a Virtual Reality (VR) program that enables the patient to choose his/her obstacles and "see" that obstacle inside his/her head.

Phase 3 will enroll 10 additional patients (different participants from phases 1 and 2) who use opioids while complaining of specific chronic pain syndrome. In this phase, the same protocol will be used, including fMRI scanning. The Virtual Reality, however, will focus specifically on creating the image of the pain in wherever the pain is being reported in the body.

Inclusion Criteria:

1. Current diagnosis of Opioid Use Disorder
2. Stable daily methadone dose for at least one month prior to enrollment
3. Desire to reduce the daily methadone dose at least 20%.

Exclusion Criteria:

1. Pregnant (urine test) or lactating (self-report)
2. Current severe Axis I psychiatric disorder, e.g. psychosis, bipolar disorder
3. Suicidal ideation/attempt during the past year
4. Medical contraindications to the proposed therapeutic program, in the opinion of the clinic physician.

People with opioid use disorder (OUD), currently enrolled in methadone maintenance treatment (MMT) who wish to learn techniques to reduce their behavioral and physiological dependence on medication.