Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 000 | Other Identifier | CTGTY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
To monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.
The primary aim of this research is to identify the most robust site for monitoring hypovolemia as well as assess changes in peripheral waveforms monitored by the pulse oximeter collected from different sites (finger, ear, forehead, and nose), blood pressure, cerebral oximetry and peripheral venous pressure during gradual hypovolemia induced by lower body negative pressure (LBNP) in healthy volunteers.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lower body negative pressure | Diagnostic Test | We will be monitoring the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers. |
| Measure | Description | Time Frame |
|---|---|---|
| Identify the most robust site for monitoring hypovolemia utilizing pulse oximeter waveforms. | Data will be summarized using mean (SD) for normally distributed data, median (interquartile range) for non-normal data. linear regression method will be used to model the changes of our dependent variable from baseline during blood loss. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Examine the relationship between central hemodynamic changes (cardiac output) with changes in respiratory variability of PPG waveforms collected from different sites during hypovolemia and fluid resuscitation | Data will be summarized using mean (SD) for normally distributed data, median (interquartile range) for non-normal data. linear regression method will be used to model the changes of our dependent variable from baseline during blood loss. |
Not provided
Inclusion Criteria:
* Healthy volunteers aged 20-45 with
Exclusion Criteria:
Not provided
Not provided
Healthy volunteers aged 20-45 with no history of heart disease, diabetes, or hypertension. Pregnant women will be excluded.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Aymen Alian, MD | Contact | 203-785-2802 | aymen.alian@yale.edu |
| Name | Affiliation | Role |
|---|---|---|
| Aymen Alian, MD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| John B. Pierce Laboratory | Recruiting | New Haven | Connecticut | 06520 | United States |
Not provided
| ID | Term |
|---|---|
| D020896 | Hypovolemia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided
| 2 years |