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| ID | Type | Description | Link |
|---|---|---|---|
| R01HD094054 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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Today's children have become increasingly inactive and unfit, with >50% of children not meeting the recommended 60 min of moderate-to-vigorous physical activity. Previous research has suggested that acute aerobic exercise of moderate intensity was associated with improved cognition manifested by improved performance and increased P3 amplitude, a neuroelectric indicator that reflects the amount of attentional allocation, in tasks requiring cognitive control. While minimal evidence exists to support potential mechanisms underlying the transient effects of exercise on brain and cognition, research suggests that phasic changes in the locus coeruleus-norepinephrine (LC-NE) (as measured by salivary alpha amylase (sAA)) system are a potential mechanism for explaining the acute effect of exercise on brain and cognition. Accordingly, the aim of this study is to examine the mechanisms linking acute aerobic exercise to improved cognitive control as well as the underlying neuroelectrical activities in children, using electroencephalography (EEG) and event-related potentials (ERPs). We hope to gain a better understanding of the role of acute exercise and cognitive and brain health. The results from this study will help identify mechanisms linking acute exercise to enhanced cognitive performance in children.
Our hypothesis is that exercise-induced phasic increases in sympathetic nervous system activity will mediate the effect of a single bout of exercise on brain function, cognition, and standardized achievement test performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aerobic Exercise Intervention | Experimental | Participants will exercise on a motor-driven treadmill at a constant speed during the 23-min period. |
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| Trier Social Stress Test for Children | Active Comparator | The Trier Social Stress Test for Children consists of a speech task in which children must finish a story and a mental arithmetic task, completed in front of a camera and two neutral observers. |
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| Seated Rest | Placebo Comparator | Participants will sit in a comfortable chair, placed in the same room as the motor-driven treadmill, for a period of 25-min. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic Exercise Intervention | Other | The protocol will include a 25-min bout of exercise at an intensity of 75% HRmax, such that participants will engage in a 1-min warm up and a 1-min cool down, with the majority of time (i.e., 23-min) spent exercising at 75% of HRmax. |
| Measure | Description | Time Frame |
|---|---|---|
| Neuroelectric outcome | P3 - ERP | baseline |
| Neuroelectric outcome | P3 - ERP | ~1 hr after arriving at lab, after completing the experimental condition |
| inhibitory control | accuracy | baseline |
| inhibitory control | reaction time | baseline |
| working memory | accuracy | baseline |
| working memory | reaction time | baseline |
| inhibitory control | accuracy | ~1 hr after arriving at lab, after completing the experimental condition |
| inhibitory control | reaction time | ~1 hr after arriving at lab, after completing the experimental condition |
| working memory | accuracy | ~1 hr after arriving at lab, after completing the experimental condition |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northeastern University | Boston | Massachusetts | 02115 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38169630 | Derived | Lloyd KM, Gabard-Durnam L, Beaudry K, De Lisio M, Raine LB, Bernard-Willis Y, Watrous JNH, Whitfield-Gabrieli S, Kramer AF, Hillman CH. Cross-sectional analysis reveals COVID-19 pandemic community lockdown was linked to dysregulated cortisol and salivary alpha amylase in children. Front Public Health. 2023 Dec 15;11:1210122. doi: 10.3389/fpubh.2023.1210122. eCollection 2023. | |
| 36733279 | Derived | Raine LB, Erickson KI, Grove G, Watrous JNH, McDonald K, Kang C, Jakicic JM, Forman DE, Kramer AF, Burns JM, Vidoni ED, McAuley E, Hillman CH. Cardiorespiratory fitness levels and body mass index of pre-adolescent children and older adults during the COVID-19 pandemic. Front Public Health. 2023 Jan 17;10:1052389. doi: 10.3389/fpubh.2022.1052389. eCollection 2022. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 28, 2026 | |
| Reset | Jun 23, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 28, 2026 | Jun 23, 2026 | |||
| Jul 8, 2026 |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| ID | Term |
|---|---|
| D004191 | Behavioral Disciplines and Activities |
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| Trier Social Stress Test for Children | Other | Participants will be asked to imagine that they are in a new class with 20 other students, and that their teacher has asked them to stand in front of the class and introduce themselves. The mental arithmetic task will entail asking children to serially subtract the number 5 from a larger number as quickly as possible. |
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| Seated Rest | Other | Children will be asked to sit quietly or read a book of their choosing. |
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| working memory | reaction time | ~1 hr after arriving at lab, after completing the experimental condition |
| Academic Achievement outcome | WRAT3 (Wide Range, Inc., Wilmington, DE) Reading Accuracy | ~1.5 hrs after arriving at lab, after completing the experimental condition |
| Academic Achievement outcome | WRAT3 (Wide Range, Inc., Wilmington, DE) Spelling Accuracy | ~1.5 hrs after arriving at lab, after completing the experimental condition |
| Academic Achievement outcome | WRAT3 (Wide Range, Inc., Wilmington, DE) Math Accuracy | ~1.5 hrs after arriving at lab, after completing the experimental condition |
| 33602325 | Derived | Raine LB, McDonald K, Shigeta TT, Hsieh SS, Hunt J, Chiarlitti NA, Lim M, Gebhardt K, Collins N, De Lisio M, Mullen SP, Kramer AF, Hillman C. Sympathetic Nervous System and Exercise Affects Cognition in Youth (SNEACY): study protocol for a randomized crossover trial. Trials. 2021 Feb 18;22(1):154. doi: 10.1186/s13063-021-05096-w. |