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The purpose of this study is to compare four different connective tissue graft harvesting technique in terms of graft quality and patient post-operative morbidity
The primary aim is to compare 4 different connective tissue graft harvesting techniques in terms of morbidity and in terms of quality of the graft.
The secondary aim is to evaluate the outcome of gingival recessions treated with grafts obtained from different harvesting approaches, in terms of mean root coverage, complete root coverage, keratinized tissue gain, clinical attachment level gain and gingival thickness
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| De-epithelialized gingival graft (DGG) | Experimental | A harvesting approach where the a graft is obtained from the superficial palate and then extra-orally de-epithelialized in order to obtain a connective tissue graft (DGG harvesting approach) Then the DGG is used for treating gingival recessions (root coverage procedure) |
|
| Envelope technique (ET) | Experimental | A harvesting approach where only one horizontal incision is performed on the palate (ET harvesting approach) for harvesting a connective tissue graft. Then the connective tissue graft is used for treating gingival recessions (root coverage procedure) |
|
| Trap door technique (TDT) | Experimental | A harvesting approach where one horizontal and two vertical incisions are performed on the palate (TDT harvesting approach) for harvesting a connective tissue graft. Then the connective tissue graft is used for treating gingival recessions (root coverage procedure) |
|
| Maxillary tuberosity (MT) | Experimental | A harvesting approach that obtains an epithelialized gingival graft from the maxillary tuberosity (MT harvesting approach) which is then extra-orally de-epithelialized in order to obtain a connective tissue graft. Then the connective tissue graft is used for treating gingival recessions (root coverage procedure) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DGG Harvesting approach | Procedure | An epithelialized graft is harvested from the superficial palate and then extraorally de-epithelialized in order to obtain a connective tissue graft |
| Measure | Description | Time Frame |
|---|---|---|
| Patient morbidity (VAS) | Patient post-operative pain measured using a VAS scale | 14 days |
| Mean root coverage (mRC) | mRC measured as a percentage | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical attachment level (CAL) gain | CAL gain measured in mm | 6 months |
| Gingival thickness (GT) | CAL gain measured in mm | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Giulio Rasperini, DDS | University of Milan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Milan | Milan | 20122 | Italy | |||
| Studio Odontoiatrico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20590963 | Background | Zucchelli G, Mele M, Stefanini M, Mazzotti C, Marzadori M, Montebugnoli L, de Sanctis M. Patient morbidity and root coverage outcome after subepithelial connective tissue and de-epithelialized grafts: a comparative randomized-controlled clinical trial. J Clin Periodontol. 2010 Aug 1;37(8):728-38. doi: 10.1111/j.1600-051X.2010.01550.x. Epub 2010 Jun 24. | |
| 29761502 |
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| ID | Term |
|---|---|
| D005889 | Gingival Recession |
| D014947 | Wounds and Injuries |
| ID | Term |
|---|---|
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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|
| ET harvesting approach | Procedure | A connective tissue graft is harvested from the palate after reflecting a primary palatal flap |
|
| TDT harvesting approach | Procedure | A connective tissue graft is harvested from the palate after reflecting a primary palatal flap |
|
| MT harvesting approach | Procedure | An epithelialized graft is harvested from the maxillary tuberosity and then extraorally de-epithelialized in order to obtain a connective tissue graft |
|
| Root coverage procedure | Procedure | A single or multiple gingival recession is treated with a coronally advanced flap and a connective tissue graft |
|
| Patient willingness for retreatment | Patient willingness for retreatment (related to graft harvesting), if necessary, expressed as "yes" or "no" | 14 days |
| Painkillers consumption | Painkiller consumption expressed in mg | 14 days |
| Root coverage Esthetic Score (RES) | RES measured using numeric values from 0 to 10 | 6 months |
| Keratinized tissue (KT) gain | KT gain measured in mm | 6 months |
| Piacenza |
| 29121 |
| Italy |
| Tavelli L, Barootchi S, Nguyen TVN, Tattan M, Ravida A, Wang HL. Efficacy of tunnel technique in the treatment of localized and multiple gingival recessions: A systematic review and meta-analysis. J Periodontol. 2018 Sep;89(9):1075-1090. doi: 10.1002/JPER.18-0066. Epub 2018 Aug 13. |
| 29713890 | Background | Tavelli L, Ravida A, Saleh MHA, Maska B, Del Amo FS, Rasperini G, Wang HL. Pain perception following epithelialized gingival graft harvesting: a randomized clinical trial. Clin Oral Investig. 2019 Jan;23(1):459-468. doi: 10.1007/s00784-018-2455-5. Epub 2018 Apr 30. |
| 18315424 | Background | Wessel JR, Tatakis DN. Patient outcomes following subepithelial connective tissue graft and free gingival graft procedures. J Periodontol. 2008 Mar;79(3):425-30. doi: 10.1902/jop.2008.070325. |
| 11203571 | Background | Lorenzana ER, Allen EP. The single-incision palatal harvest technique: a strategy for esthetics and patient comfort. Int J Periodontics Restorative Dent. 2000 Jun;20(3):297-305. |
| D055093 |
| Periodontal Atrophy |