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The goal of this study is to implement a non-invasive version of the sweat secretion test based in visualization of sweat glands following β-adrenergic stimulation of sweat. Specifically, the trial will evaluate the relative response of sweat glands to β-adrenergic and cholinergic stimulation among participants with CF, heterozygous and matched control subjects
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with mucoviscidosis | Experimental | For patients with cystic fibrosis: clinically stable, all genotypes included. |
|
| Parents of patients with confirmed diagnosis of mucoviscidosis | Experimental | The parents are heterozygous subjects |
|
| Healthy volunteers | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Iontophoresis sessions in forearm of subjects with pilocarpine | Diagnostic Test | The test with two iontophoresis sessions is performed in a forearm of subjects. Pilocarpine is applied during the first iontophoresis session to evoke cholinergic-induced sweat secretion. Atropine, isoprenaline and aminophylline are applied during the second iontophoresis session, to block the cholinergic component and to evoke β-adrenergic-induced sweat secretion. |
| Measure | Description | Time Frame |
|---|---|---|
| Ratio between the β-adrenergic/cholinergic rate | The ratio between the β-adrenergic/cholinergic rate (nL/min) of droplets of sweat is calculated. | up to 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Teresinha LEAL, Biologist | Contact | 00 32 2 764 | 94 73 | teresinha.leal@uclouvain.be |
| Audrey REYNAERTS, Sciences | Contact | 00 32 2 764 | 94 72 | audrey.reynaerts@uclouvain.be |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cliniques universitaires Saint-Luc | Recruiting | Brussels | 1200 | Belgium |
There is no plan now
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Intervention Model: Three Group Assignment
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|
| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
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