Implementation of a Non-invasive Version of the Imaging β-adrenergic-dependent Sweat Secretion Test

Implementation of a Non-invasive Version of the Imaging β-adrenergic-dependent Sweat Secretion Test: Value for Diagnosis and Efficacy of Target Therapies for Cystic Fibrosis

The goal of this study is to implement a non-invasive version of the sweat secretion test based in visualization of sweat glands following β-adrenergic stimulation of sweat. Specifically, the trial will evaluate the relative response of sweat glands to β-adrenergic and cholinergic stimulation among participants with CF, heterozygous and matched control subjects

Inclusion Criteria:

• For patients with cystic fibrosis: clinically stable, all genotypes included.
• For healthy volunteer and heterozygous subjects: 18 years and older.

Exclusion Criteria:

• Corticosteroids, anti-leukotriene therapy, unstable clinical status, <40% FEV1.
• Current pregnancy or breastfeeding.