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The main objective of the present project is to develop an imaging-based tool to determine the origin and cause of persistent atrial fibrillation (AF). The result of the study is a diagnostic method which aids the medical work-up of patients suffering from this disease.
Atrial fibrillation (AF) is the most common arrhythmia associated with substantial morbidity and mortality in humans. Histopathological studies of persistent AF have reported extracellular matrix remodeling with fibrotic infiltration which may cause atrial dilation. The degree of the fibrosis might have a significant impact on wave propagation during AF. The main objective of the present project is to develop an imaging-based tool to determine the origin and cause of persistent AF. The obtained clinical parameters of patients and controls (electrocardiography, ecocardiography and MR imaging data) will be correlated with known markers in order to identify novel markers for AF diagnosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with AF | Patients with atrial fibrillation visiting the outpatient clinic; examined by general examination, electrocardiography, ecocardiography and MRI. |
| |
| Control | Healthy adult volunteers; examined by the study physicians by general examination, electrocardiography, ecocardiography and MRI. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Electrocardiography, ecocardiography and MRI. | Diagnostic Test | AF patients and healthy adult volunteers will be examined by the study physicians and included in the study according to the inclusion criteria. After a general examination, an electrocardiography, an ecocardiography and an MRI will be performed on the AF-affected and healthy hearts, respectively. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of the presence, localization and quantity of left atrial fibrosis assessed by MRI in patients with persistent atrial fibrillation. | A. Percentage of patients with left atrial fibrosis assessed by MRI among those with persistent atrial fibrillation. B. Correlation of the left atrial fibrosis localization and amount with persistent atrial fibrillation severity. | 2016-2020 |
| Measure | Description | Time Frame |
|---|---|---|
| Specificity of left atrial fibrosis for persistent atrial fibrillation by comparing fibrosis in patients and healthy volunteers. | A. Correlation of left atrial fibrosis with left atrial dimensions in patients and healthy volunteers. B. Correlation of left atrial fibrosis with blood bio-marker levels and echocardiography parameters in patients and healthy volunteers. | 2016-2020 |
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Inclusion Criteria:
Exclusion Criteria:
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Adult population presented at the cardiologist with persistent, permanent or paroxysmal atrial fibrillation (AF).
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| Name | Affiliation | Role |
|---|---|---|
| Zoltán Bálint, PhD | County Clinical Emergency Hospital Cluj-Napoca | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| County Clinical Emergency Hospital of Cluj-Napoca | Cluj-Napoca | Cluj | 400006 | Romania |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41010636 | Derived | Manole S, Pintican R, Budurea C, Pop S, Iancu SD, Popa L, Coman M, Schiau C, Coman V, Schiau S, Balint Z. Increased Left Ventricular Mass Index and Atrial Volume Index Are Associated with Atrial Fibrosis in Patients with Atrial Fibrillation. J Clin Med. 2025 Sep 12;14(18):6432. doi: 10.3390/jcm14186432. |
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| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D004562 | Electrocardiography |
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Blood
|
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D004568 | Electrodiagnosis |
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |