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Cardiogenic shock is an uncommun pathology with a high mortatily rate around 45%. Veno arterial extracorporeal membrane oxygenation (VA-ECMO) is a temporary extracorporeal assist device which restore an adequate blood flow when a circulatory failure occures. VA-ECMO main indication is refractory cardiogenic shock whatever the etiology. Current medical care of terminal cardiac failure includes use of long-term mechanical circulatory support devices (MCSD) such as Left Ventricular Assist Device (LVAD). LVAD therapy may lead to heart transplant (bridge to transplantation), to recovery (bridge to recovery) or to permanent implantation (destination therapy). Few patients with refractory cardiogenic shock treated with VA-ECMO may secondarily need a long term MCSD with LVAD.
LVAD long-term heart assist showed interesting survival rate when implantation occured (71% after 2 years follow-up and 45% after 4 years follow-up) out of acute heart failure situation. There are only few datas concerning LVAD implantion during refractory cardiogenic shock, with a mortality between 20 to 50% in different studies.
In this way, in comparaison of current few datas on the subject of LVAD implantation under VA-ECMO, the investigators (15 french-speacking centers) would retrospectively describe a large population.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Left Ventricular Assist Device Implantation | Device | Veno-arterial extracorporeal membrane oxygenation prior to left ventricular assist device implantation : initial patients characteristics and 6 Month Follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| 6-month hospital discharge after LVAD implantation | 6-month hospital discharge after LVAD implantation | 6 month after LVAD implantation |
| Measure | Description | Time Frame |
|---|---|---|
| Mortality rate | Six month mortality rate after LVAD implantation | up to six month after LVAD implantation |
| ICU discharge | Days until ICU discharge after LVAD implantation |
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamic Failure | Amount of Norepinephrine infused | Before LVAD implantation - up to 28 day - up to 6 month |
| Cardiogenic failure | Amount of inotrope infused |
Inclusion Criteria:
Exclusion Criteria:
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All patients between 01.01.2013 and 31.12.2017 in the participating centers implanted with LVAD during VA-ECMO therapy for refractory cardiogenic shock.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Caroline Fritz, MD | Contact | +3383157379 | fritzcaro@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Bruno Levy, MD-PhD | CHRU Nancy | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Nancy | Recruiting | Nancy | 54000 | France |
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| up to six month after LVAD implantation |
| Quality of life | ADL and IADL scale | up to six month after LVAD implantation |
| Before LVAD implantation - up to 28 day - up to 6 month |
| Cardio-circulatory failure | ECLS assistance | Before LVAD implantation - up to 28 day - up to 6 month |
| Renal failure | Worst KDIGO stage | Before LVAD implantation - up to 28 day - up to 6 month |
| Hepatic failure | Worst values of PT/bilirubin/ AST and ALT | Before LVAD implantation - up to 28 day - up to 6 month |
| Thrombosis complication | Thrombosis event | Before LVAD implantation - up to 28 day - up to 6 month |
| Haemorragic complication | Haemorragic event | Before LVAD implantation - up to 28 day - up to 6 month |
| Respiratory failure | Ventilation assistance | Before LVAD implantation - up to 28 day - up to 6 month |
| Neurological failure | neurological sequelae | Before LVAD implantation - up to 28 day - up to 6 month |
| Infection complication | documented infection | Before LVAD implantation - up to 28 day - up to 6 month |
| ID | Term |
|---|---|
| D012770 | Shock, Cardiogenic |
| D006333 | Heart Failure |
| D002318 | Cardiovascular Diseases |
| D009203 | Myocardial Infarction |
| D017202 | Myocardial Ischemia |
| D012769 | Shock |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
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