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Is there a difference in the eating process for patients with active Eosinophilic Esophagitis (EoE) and those with inactive disease?
Eosinophilic esophagitis (EoE) patients develop adapted eating behaviors to prevent symptoms. These patients tend to cut their food small, chew extensively, take copious liquids with meals, and avoid foods that cause symptoms. No studies to date have directly evaluated these eating behaviors in patients with EoE with observation. Furthermore, none of the investigators' current metrics for patient symptom assessment visually evaluate the eating process nor are they compared before and after treatment. As a result, it is unclear if a patient's subjective perception of their eating difficulties and improvement matches with objective measures.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acitve EoE | Observed eating session of Jimmy John's turkey or vegetarian sandwich with water among individuals who have EoE who have not been treated or have not achieved remission from treatment. |
| |
| Remission EoE | Observed eating session of Jimmy John's turkey or vegetarian sandwich with water among individuals who have EoE who are have achieved remission from treatment. |
| |
| Controls | Observed eating session of Jimmy John's turkey or vegetarian sandwich with water among individuals without EoE. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observed eating session | Behavioral | Eating a Jimmy Johns turkey or vegetarian sandwich |
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| Measure | Description | Time Frame |
|---|---|---|
| Observed eating session | number of bites of patient's with EoE and controls eating a Jimmy John's sandwich | 15-90 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Food slowness during eating session | number of bites that felt stuck among patients with EoE and controls when eating a Jimmy John's sandwich | 15-90 minutes |
| Water during eating session | amount of water drank of patients with EoE and controls eating a Jimmy John's sandiwch |
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Inclusion Criteria:
Exclusion Criteria:
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Individuals with EoE that are being seen at Mayo Clinic Esophageal Clinic will be approached. Controls will be individuals who do not have an EoE diagnosis.
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| Name | Affiliation | Role |
|---|---|---|
| Jeffrey A Alexander | Mayo Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | United States |
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| Label | URL |
|---|---|
| Mayo Clinic Clinical Trials | View source |
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| ID | Term |
|---|---|
| D057765 | Eosinophilic Esophagitis |
| D003680 | Deglutition Disorders |
| ID | Term |
|---|---|
| D004941 | Esophagitis |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| 15-90 minutes |
| Eosinophilic Esophagitis activity Index (EEsAI) questionnaire | The EEsAI Pro uses the VDQ is visual dysphagia question AMS is avoidance, modification, slow eating question . These two along with questions on frequency of, duration of, pain associated with dysphagia make up the PRO (patient reported outcomes). The PRO is a number (0-100) calculated from the answer to the questions. A PRO < 20 defines asymptomatic EoE. | 10-15 minutes |
| Eosinophilic Esophagitis Quality of Life questionnaire | Higher score denote better quality of life. 0-4 as follows 4=not at all, 3=Slightly 2=moderately, 1=Quite a bit, 0= Extremely | 10-15 minutes |
| D005759 |
| Gastroenteritis |
| D004802 | Eosinophilia |
| D007960 | Leukocyte Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D010608 | Pharyngeal Diseases |
| D010038 | Otorhinolaryngologic Diseases |