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The primary purpose of the study is to identify clinical, radiological and genetic diagnostic criteria for Primary Failure of Eruption (PFE).
The secondary purposes are to highlight the genotype-phenotype correlations in the PTHR1 and non-PTHR1 forms and analyze the therapeutic failures.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| genetic analysis | Genetic | saliva is collected for DNA extraction | ||
| panoramic radiography | Radiation | panoramic radiography | ||
| teleradiography | Radiation | teleradiography | ||
| intraoral X-rays | Radiation | intraoral X-rays | ||
| CT scan of maxillary and mandible | Radiation | CT scan of maxillary and mandible |
| Measure | Description | Time Frame |
|---|---|---|
| Number of teeth | number of teeth | at inclusion (day 1) |
| Recording of dental caries | recording of dental caries by Decayed Missing Filled Teeth index (DMFT index) | at inclusion (day 1) |
| Recording the location of dental caries | the number of teeth affected using the international classification index | at inclusion (day 1) |
| Drugs intra uterine exposure | drugs during pregnancy | at inclusion (day 1) |
| Nutritional deficiencies | nutritional deficiencies assessed by a questionnaire | at inclusion (day 1) |
| Periodontium | assessment of the periodontium by Maynard and Wilson classification | at inclusion (day 1) |
| Oral hygiene | assesment of oral hygiene by plaque index (Löe and Silness, 1963) | at inclusion (day 1) |
| Gingival inflammation | assesment of gingival inflammation by gingival index (Löe and Silness, 1963) | at inclusion (day 1) |
| Measure | Description | Time Frame |
|---|---|---|
| Mutations causing PFE | at inclusion (day 1) | |
| Type of treatment performed | (orthodontics, surgery, prothesis) | at inclusion (day 1) |
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Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marion STRUB, Doctor | Contact | 388116956 | 0033 | marion.strub@chru-strasbourg.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Clinique dentaire | Recruiting | Strasbourg | 67000 | France |
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single group
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| Treatment needs | assessment of treatment needs using Community Periodontal Index of treatment Needs (CPITN) | at inclusion (day 1) |
| Face shape | assesment of the face shape : round, square, oval | at inclusion (day 1) |
| Symmetry of the face | symmetry of the face (yes/no) | at inclusion (day 1) |
| Profile (shape) | assessment of the profile (shape) | at inclusion (day 1) |
| Smile | morphology of the smile | at inclusion (day 1) |
| Vertical dimension | assessment of the vertical dimension: anterior infraclusion or overbite (in %) | at inclusion (day 1) |
| Transversal dimension | assessment of the transversal dimension: posterior transversal dimension (in mm) | at inclusion (day 1) |
| Sagittal dimension | Assessment of the sagittal dimension by Angle's classification | at inclusion (day 1) |
| Chewing | Assessment of chewing by Plana's Functional Masticatory Angles (PFMA) | at inclusion (day 1) |
| Nasal breathing | Assessment of nasal breathing by the Rosenthal's test | at inclusion (day 1) |
| Swallowing | Assessment of swallowing by lingual interposition | at inclusion (day 1) |
| ID | Term |
|---|---|
| D005820 | Genetic Testing |
| D011862 | Radiography, Panoramic |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D005821 | Genetic Techniques |
| D033142 | Genetic Services |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D003954 | Diagnostic Services |
| D011314 | Preventive Health Services |
| D011861 | Radiography, Dental |
| D011859 | Radiography |
| D003952 | Diagnostic Imaging |
| D003945 | Diagnosis, Oral |
| D003813 | Dentistry |
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