This will be a prospective study that will enroll up to 2000 MSM and TG from community-based clinics in Bangkok, Chonburi, Chiang Mai, and Songkhla.

Eligible participants will be followed up until the completion of a 12-month period. All participants will be followed up every 3 months. An additional follow up visit at month 1 will be made for participants who PrEP is initiated at entry visit (those who already received PrEP prior to the study will not need the additional visit).

Study Sites

The study will take place at the following community-based clinics:

1. SWING DIC, Bangkok, Thailand
2. RSAT DIC, Bangkok, Thailand
3. SWING DIC, Chonburi, Thailand
4. Sisters DIC, Chonburi, Thailand
5. Mplus DIC, Chiang Mai, Thailand
6. RSAT DIC, Songkhla, Thailand

Inclusion Criteria:

1. Thai nationality

2. Age ≥ 18 years old

3. Men or transgender women who have sex with men

4. Have at least one of the following risks for HIV acquisition in the past 6 months:

   • Any unprotected receptive anal sex
   • More than 5 sexual partners, regardless of condom use and serostatus
   • History of syphilis, chlamydia or gonorrhea diagnosed or treated
   • Any stimulant drug use

5. Have signed the consent form

Exclusion Criteria:

• None

Approximately 2000 MSM and TG