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| Name | Class |
|---|---|
| Oregon Health and Science University | OTHER |
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One of the principal complicating factors associated with traumatic brain injury (TBI) is sleep-wake disturbances (e.g., insomnia, excessive daytime sleepiness, and circadian rhythm sleep disorders). Morning bright light therapy (MBLT) has been shown to improve sleep quality in a variety of conditions, but little has been done investigating the utility of MBLT in improving sleep in Veterans with TBI. This proposal aims to determine the effect of MBLT on sleep quality in Veterans with TBI. Veterans with and without TBI will be recruited from the VA Portland Health Care System. Baseline questionnaires and 7 days of actigraphy will be collected prior to engaging in 60 minutes of MBLT daily for 4 weeks, during which actigraphy will also be collected continuously. Post-MBLT questionnaire data will be collected, and follow-up questionnaire data will be collected at 3 months post-MBLT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Morning Bright Light Therapy | Experimental | Subjects who engage in morning bight light therapy |
|
| Control | No Intervention | Subjects who do not engage in morning bright light therapy |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Morning Bright Light Therapy | Other | 60 minutes of bright light therapy (10,000 lux) received within 90 minutes of waking |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Insomnia Severity Index (ISI) | Measures self-reported insomnia severity; total score range = 0-28 (higher total score = worse insomnia) | Baseline; after 4 weeks of intervention; and 2 months after the end of intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Miranda M Lim, MD, PhD | Contact | 503-220-8262 | 57404 | lmir@ohsu.edu |
| Jonathan E Elliott, PhD | Contact | 503-220-8262 | 58020 | elliojon@ohsu.edu |
| Name | Affiliation | Role |
|---|---|---|
| Miranda M Lim, MD, PhD | Portland VA Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Portland Health Care System | Recruiting | Portand | Oregon | 97239 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35421086 | Derived | Elliott JE, McBride AA, Balba NM, Thomas SV, Pattinson CL, Morasco BJ, Wilkerson A, Gill JM, Lim MM. Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial. PLoS One. 2022 Apr 14;17(4):e0262955. doi: 10.1371/journal.pone.0262955. eCollection 2022. |
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All non-identifiable data will be made available to qualified researchers on request to the study PI.
Information will be sent as soon as is practical and will be available as long as the PI is available.
Legitimate research agenda, including but not limited to request to double-check presented or published results and novel analyses.
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D013313 | Stress Disorders, Post-Traumatic |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| D006259 |
| Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D040921 | Stress Disorders, Traumatic |
| D000068099 | Trauma and Stressor Related Disorders |
| D001523 | Mental Disorders |