Purpose of the trial:

Trial design: Two-parallel arm, double-blind, individually randomized controlled trial.

Primary endpoint:

Clinical evaluation of sinus, oropharyngeal, tracheal, bronchial or pulmonary infections during orotracheal intubation and hospital admission.

Secondary endpoints:

Volume of oropharyngeal secretions aspirated per unit of time (for 24 hours) by the SupraTube and Complications during the use of the SupraTube device: erosions, lacerations, Bleeding, displacement, migration, need for withdrawal.

Inclusion criteria:

• Adult patient
• Orotracheal intubation ≤ 72 hours
• Hospitalized in ICU
• integrity of upper airways

Exclusion criteria:

• International patients
• Coagulopathic patients
• oncology patients
• patients with maxillofacial surgery
• Absence of close responsible family member
• Tracheostomy, shock, local or systemic non-controlled infection

Trial treatment:

Intervention:

Aspiration of secretions with the supranav device

Control:

Usual respiratory care

Expected sample size, enrollment and expected number of centers:

Sample size = 108

Recruitment start date:

Recruitment end date:

Follow-up end date:

Number of centers: 2

Statistical considerations:

• Intention to treat analysis
• The primary outcomes will be analyzed using

Inclusion Criteria:

• Intubated adult patients with mechanical ventilation.
• To have a closest responsible relative
• Integrity of the airways

Exclusion Criteria:

• Need of orofacial, cervical or respiratory tract surgical procedures
• Patients with tracheostomy
• Shock,
• Local or systemic uncontrolled infection
• Blood dyscrasia, neoplastic diseases
• Physiological alteration
• Acute or chronic decompensated pathology that is not controlled at the time of selection.