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The aim of the research is to evaluate the clinical value of fractional exhaled nitric oxide(FeNO) ,impulse oscillometry(IOS) and mid-expiratory flow (MEF) in patients with cough variant asthma.
The present study has the following objectives:
to evaluate the relationship between BHR and mid-expiratory flow, to assess the diagnostic accuracy of fractional exhaled nitric oxide，impulse oscillometry and mid-expiratory flow in CVA with special regard to its discriminating value between CVA and other causes of a chronic cough, to estimate prognostic value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Asthma group | Experimental | Patients with chronic nonproductive cough for more than 8 weeks based on physician's opinion will be subjected to FeNO, impulse oscillometry(IOS) and pulmonary function. Receiver operating characteristic (ROC) curves to evaluate the clinical value of FeNO and small airways indices in CVA diagnosis. The optimal cutoff point for the level of FeNO and IOS is also determined. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fractional exhaled nitric oxide(FeNO) | Diagnostic Test | FeNO level was evaluated according to the American Thoracic Society (ATS)/ERS recommendations using a NIOX MINO analyzer (Aerocrine, Solna, Sweden) .Subjects were informed to deeply inhale NO-free air and immediately exhale in full via a mouthpiece at a constant flow rate (50 ml/s) for 10s. |
| Measure | Description | Time Frame |
|---|---|---|
| the value of fractional exhaled nitric oxide(FeNO) in patients with cough variant asthma | FENO will be performed by using a hand-held portable machine (NIOX MINO, Aerocrine AB, Solna, Sweden) at a standard flow rate of 50 mL/s, in accordance with ATS/ERS recommendations. | at least 4 weeks of treatment |
| the value of impulse oscillometry(IOS) in patients with cough variant asthma | R5-R20（respiratory resistance）is measure by Jaeger MasterScreen Pulmonary | at least 4 weeks of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| the value of forced mid-expiratory flow (MMEF) in patients with cough variant asthma | MMEF will be performed with a spirometer (Jaeger, Hoechberg, Germany) in accordance with the specifications and performance criteria recommended in the American Thoracic Society (ATS)/European Respiratory Society (ERS) Standardization of Spirometry | at least 4 weeks of treatment |
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Inclusion Criteria:
age 18-65 years old. Cough as the sole or predominant symptom lasting for at least 8 weeks, with no radiographic evidence of lung diseases.
Exclusion Criteria:
treatment of any oral corticosteroid in the last 4 weeks, and respiratory tract infection within 8 weeks.
smoking (min. 6 months) had asthma or other lung diseases, including obliterative bronchiolitis, bronchiectasis,and cystic fibrosis.
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| Name | Affiliation | Role |
|---|---|---|
| Yu Hupeng | Southern Medical University, China | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Huapeng Yu | Guangzhou | Guangdong | China |
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| ID | Term |
|---|---|
| D000096823 | Cough-Variant Asthma |
| D000096822 | Chronic Cough |
| ID | Term |
|---|---|
| D001249 | Asthma |
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
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| ID | Term |
|---|---|
| D000089142 | Fractional Exhaled Nitric Oxide Testing |
| ID | Term |
|---|---|
| D001944 | Breath Tests |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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|
| impulse oscillometry(IOS) | Diagnostic Test | The patient take seats, body relax, make sure the mouthpiece is fully covered by mouth, then clip nose with both hands to cover both sides of the cheek, and then calm breathing 1 minutes, the computer is automatically collected data calculation and print out the measurement results. |
|
| the value of BHR and fractional exhaled nitric oxide (FeNO) count in predicting response to asthma treatment | MCH bronchial provocation tests will be performed with the Jaeger APS Pro system.Provocative dose causing a 20% fall in FEV1(PD20) will be recorded, and BHR is defined as present if PD20≤0.48 mg. FENO is measure by a hand-held portable machine(NIOX MINO, Aerocrine AB, Solna, Sweden) | at least 4 weeks of treatment |
| the relationship between BHR and mid-expiratory flow | BHR is measure by Jaeger APS Pro system.MMEF will be performed with a spirometer (Jaeger, Hoechberg, Germany) | at least 4 weeks of treatment |
| D008171 |
| Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D003371 | Cough |
| D012120 | Respiration Disorders |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |