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| Name | Class |
|---|---|
| Sigma Theta Tau | UNKNOWN |
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Genotype 164 adults to evaluate six selected single nucleotide polymorphisms (SNPs) (rs1006737, rs10994336, rs10994133, rs2238071, rs1051375, rs1024582) for use as a genetic biomarker to differentiate between bipolar depression and unipolar depression.
Adults ages 18-80 will be recruited if they are diagnosed with bipolar disorder, major depression, or have no mood symptoms. The adults will undergo a diagnostic interview, the Mini International Neuropsychiatric Interview (MINI) for the diagnosis. The subjects will also complete the Adverse Childhood Events Scale to evaluate for a genetic x environmental interaction in detecting bipolar disorder at initial assessment. Genotyping will be done by SNaPshot genotyping method and genetic sample will be collected via buccal swab.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bipolar | Diagnosed as having at least 1 lifetime manic episode by the MINI |
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| Depression | Diagnosed as having at least 1 Major Depressive Episode by the MINI |
| |
| Healthy Controls | Does not meet Criteria for any mood disorder diagnosis (MDD, BD, dysthymia) |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| genotyping all subjects | Other | genotyping using SNaPshot genotyping method. |
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| Measure | Description | Time Frame |
|---|---|---|
| Logistic Regression | Logistic regression will be used to examine a genetic risk score using a risk allele count as the independent variable, with a diagnosis of BD versus MDD versus those with no mood diagnosis as the dependent variable. | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic Risk Score | Genetic risk score of selected SNPsrs1006737, rs10994336, rs10994133, rs2238071, rs1051375, rs1024582 | 1 year |
| Family History | Positive family history of bipolar disorder in a first degree relative |
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Inclusion Criteria:
Exclusion Criteria:
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Caucasian and Latino
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| Name | Affiliation | Role |
|---|---|---|
| Kristiana Avery, PhD-c | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Helen and Arthur E Johnson Depression Center | Aurora | Colorado | 80045 | United States |
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| ID | Term |
|---|---|
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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Buccal Swab collect with genotyping done by SNaPshot.
| 1 year |
| Adverse Childhood Experiences Scale | 0-10 item scale assessing for adversity experienced during childhood | 1 year |