Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study was designed to quantify the incidence of hyponatremia in patients of supratentorial/supra-sellar lesions and observe their effect on neurological morbidity and mortality.
Disorders of sodium and water balance are one of the commonly encountered problems while managing patients with neurological diseases. Managing such problems are challenging because the pathophysiology behind these disorders are complex and poorly understood and treatment of the injured brain itself can contribute to, and complicate the diagnosis of sodium disorders. Serum sodium disturbance can manifest as hypernatremia or hyponatremia. Hypernatremia usually occurs in the diabetes insipidus syndrome, whereas hyponatremia develops as a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) or cerebral salt-wasting syndrome (CSWS).
Because of the cerebral effects of hyponatremia, neurosurgical patients are at increased risk of complications including severe cerebral edema, mental status changes, seizures, vasospasm, and death.
Though the problem of hyponatremia has been addressed in patients with different brain pathologies, this has not been studied in patients with non-sellar/suprasellar supratentorial tumors. This study was envisioned to quantify the incidence and magnitude of hyponatremia in this patient population and their subsequent neurological morbidity and mortality.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Retrospective Cohort | Supratentorial/Suprasellar brain tumor patients with Glasgow Coma Score > 3 at time of admission. |
| |
| Prospective Cohort | Supratentorial/Suprasellar brain tumor patients with Glasgow Coma Score > 3 at time of recruitment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Serum Sodium | Diagnostic Test | Measurement of serum sodium. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality | To observe relationship between hyponatremia in supratentorial tumor patients and in-hospital mortality. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. |
| Measure | Description | Time Frame |
|---|---|---|
| Duration of hospital stay | To observe relationship between hyponatremia in supratentorial tumor patients and duration of hospital stay. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. |
| Rate of admission in intensive care unit. |
Not provided
Inclusion Criteria:
Patients undergoing surgical management for supratentorial/suprasellar tumors.
Exclusion Criteria:
Glasgow Coma Score (GCS) <4.
Not provided
Not provided
Not provided
Patients admitted to NIMHANS for surgical management of Supratentorial/Suprasellar tumor management with GCS > 3 at recruitment (for prospective cohort) or admission (for retrospective cohort).
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D007010 | Hyponatremia |
| ID | Term |
|---|---|
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
To observe relationship between hyponatremia in supratentorial tumor patients and rate of admission in intensive care unit. |
| From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. |
| Neurological deficits | To observe relationship between hyponatremia in supratentorial tumor patients and incidence of neurological deficits. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. |
| Seizures | To observe relationship between hyponatremia in supratentorial tumor patients and incidence of seizures. | From date of admission to hospital to date of Discharge from hospital or Death in hospital, whichever comes first, assessed up to 2 years from date of admission. |