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| Name | Class |
|---|---|
| Vendee Departmental hospital center | UNKNOWN |
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Identify gut microbiome biomarkers associated with colitis in patients treated with targeted therapy in hematology
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| Measure | Description | Time Frame |
|---|---|---|
| difference in microbiome biomarkers between patients developing colitis after exposure to targeted therapy and those not developing colitis | With the different species and metabolites between the 2 groups of patients (patients developing diarrhea after exposure to Ibrutinib and those not developing diarrhea), we will create a risk score for occurrence of diarrhea during treatment with Ibrutinib, on the previously developed model (Montassier et al, 2016, Genome medicine) | At the end of the study, after 2 years. |
| Measure | Description | Time Frame |
|---|---|---|
| Identify biomarkers of the gut microbiota associated with the occurrence of severe diarrhea (grade 3 and 4 CTCAE, version 4.0) in patients treated with Ibrutinib for malignant hemopathy B. | At the end of the study, after 2 years. | |
| Identify biomarkers of gut microbiota associated with the occurrence of diarrhea by subgroup: patients treated with Ibrutinib alone, patients treated with Ibrutinib in combination with another molecule |
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Inclusion Criteria:
Exclusion Criteria:
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All patients hospitalized in the Hematology departments and receiving targeted therapy with Ibrutinib
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emmanuel MONTASSIER, MD | Contact | 02 53 48 20 38 | +33 | emmanuel.montassier@chu-nantes.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nantes | Nantes | France |
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Stool samples and blood samples
| At the end of the study, after 2 years. |
| Creation of a predictive score of the occurrence of diarrhea in patients treated with Ibrutinib for malignant hemopathy B, including the biomarkers of the intestinal microbiome and the clinical characteristics of the patient | At the end of the study, after 2 years. |