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Radiation-associated carotid vasculopathy is a common late sequelae in patients with head and neck cancer, which correlates with the incidence of stroke. Currently, little is known about the incidence of radiation-associated carotid vasculopahty in the context of intensity-modulated radiation therapy (IMRT).
The aim of this study is to determine whether IMRT will increase the incidence of carotid vasculopathy in patients with nasopharyngeal carcinoma (NPC).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| the post-radiation group | patients diagnosed as non-metastatic nasopharyngeal carcinoma who received definitive IMRT more than 3 years ago |
| |
| the pre-radiation group | untreated patients diagnosed as non-metastatic nasopharyngeal carcinoma |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurement of intima media thickness of carotid artery | Diagnostic Test | IMT measurements were performed using ultrasound machine in the pre-radiation and the post-radiation group. IMT was assessed at the common carotid artery (CCA) and the internal carotid artery (ICA) of both the left and right side. |
| Measure | Description | Time Frame |
|---|---|---|
| intima media thickness of carotid artery | the intima media thickness of common carotid artery, internal carotid artery of the left or right side | This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics. |
| Measure | Description | Time Frame |
|---|---|---|
| the incidence of carotid stenosis | Carotid stenosis is defined as the axial diameter of the carotid lumina decreases more than 50%. | This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics. |
| the number of carotid plaques |
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Inclusion Criteria:
Exclusion Criteria:
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The study population is selected from new patients or post-radiation patients who come to the clinics of radiation oncology.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xiaomin Ou, MD | Contact | +86 13816287320 | doctorou1012@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xiayun He, MD | Fudan University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fudan University Shanghai Cancer Center | Shanghai | Shanghai Municipality | 200032 | China |
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|
| Detection and measurement of carotid plaques | Diagnostic Test | Detection and measurement of plaques within internal carotid artery and common carotid artery by ultrasound |
|
| Carotid Color Flow Duplex Testing | Diagnostic Test | Velocity measurement of carotid artery to determine carotid stenosis |
|
| Montreal Cognitive Assessment | Diagnostic Test | Cognitive assessment |
|
| Medical history of cardiovascular risk factors and cardiovascular diseases | Other | Cardiovascular risk factors include smoking, alcohol consumption, hypertension, diabetes mellitus, hypercholesterolemia, obesity. Cardiovascular diseases include ischemic stroke, ischemic coronary heart disease, TIA, etc. |
|
Carotid plaque is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness >1.5 mm as measured from the media-adventitia interface to the intima- lumen interface. |
| This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics. |
| total number of Montreal Cognitive Score (range: 0-30) | the higher the number, the better the cognitive function | This is a cross-sectional study. So the time frame is within one week of a patient-visit to the clinics. |
| ID | Term |
|---|---|
| D000077274 | Nasopharyngeal Carcinoma |
| D002340 | Carotid Artery Diseases |
| ID | Term |
|---|---|
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009303 | Nasopharyngeal Neoplasms |
| D010610 | Pharyngeal Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D006258 | Head and Neck Neoplasms |
| D009371 | Neoplasms by Site |
| D009302 | Nasopharyngeal Diseases |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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