Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Post-craniotomy emergence hypertension is a common phenomenon that may predispose to development of intracranial hematoma and cerebral edema.The aim of this study is to compare the safety and efficacy of Mgso4 versus lidocaine infusion for control of emergence hypertension after craniotomy.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnesium sulphate | Active Comparator | 50 mg/kg over 10 minutes loading followed by 15mg/kg/hr infusion |
|
| lidocaine hydrochloride | Active Comparator | 1.5mg/kg loading followed by 2mg/kg/hr infusion |
|
| NaCl 0.9% normal saline | Placebo Comparator | Normal saline infusion with the same rate as the study drugs |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magnesium sulphate | Drug | Magnesium sulphate 50 mg/kg over 10 minutes loading followed by 15mg/kg/hr infusion. . |
|
| Measure | Description | Time Frame |
|---|---|---|
| postcraniotomy emergence hypertension response to the study drugs | The number of the patients who have systolic blood pressure below 140 mmH during emergence of anesthesia after craniotomy for brain tumors in each group | 4hours |
| Measure | Description | Time Frame |
|---|---|---|
| Recovery time | Time till discharge from PACU | 2 hours |
| Incidence of side effects of the used drugs | measure of safety | 4 hours |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed ELbadawy, MD | Contact | 01064249076 | 11562 | elbadawyahmed89@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Ahmed ELbadawy, MD | Faculty of medicine- Cairo University- Egypt | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ahmed ELbadawy | Recruiting | Cairo | 02 | Egypt |
Not provided
| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D008278 | Magnesium Sulfate |
| D008012 | Lidocaine |
| D000077330 | Saline Solution |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Lidocaine Hydrochloride | Drug | lidocaine hydrochloride 1.5mg/kg loading followed by 2mg/kg/hr infusion |
|
|
| Normal saline | Drug | Normal saline infusion with the same rate of infusion as the study drugs |
|
|
| D013456 |
| Sulfur Acids |
| D013457 | Sulfur Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D017670 | Sodium Compounds |