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Abnormal body composition with increased body fat mass and decreased lean body mass has been found in adults with Prader-Willi syndrome (PWS), contributing to reduced physical capacity and impairment. The aim of this study was to investigate whether progressive elastic band resistance training can improve physical motor performance and regional body composition in adults with PWS.
Six participants were enrolled in this pilot study. Following 24 weeks of progressive elastic band resistance exercise training, significant reduction was observed in their body weight, BMI, and regional extremities fat mass and percentage. Regarding the functional performances, there were also significant improvements in their hand grip strength, 3 meter timed up and go, 30 seconds sit to stand, and 2-min step up tests, as early as the 8th week of training. Balance function achieved significant improvements after 16 weeks of training.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PWS elastic band training group | Experimental | Genetically confirmed diagnosis of PWS participants were recruited. The PWS participants needed to have sufficient command of the Mandarin language to understand the study information and motivated to conduct the training program. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PWS elastic band training group | Device | PWS participants received 9 sets exercises for the major muscle groups, over 24 weeks, three times a week, for a total of 72 sessions. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in the handgrip strength functional physical assessment | hand grip strength (pounds), | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks |
| Changes in the 30 second chair stand functional physical assessment | 30-second chair stand test (times) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks |
| Changes in the timed up and go functional physical assessment | timed up-and-go test (seconds) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks |
| Changes in the two minute step up functional physical assessment | 2 minute step up test (times) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks |
| Changes in the balance functional physical assessment | Berg Balance Scale (0-56 points; 0-20= high fall risk; 21-40= medium fall risk; 41-56= low fall risk) | Changes from Baseline functional motor performance tests at 8 weeks, 16 weeks and 24 weeks |
| Change in the BMI body composition | Body weight (km) and height (m) will be combined to report as BMI (kg/m2) | Change from Baseline body composition components at 6 months |
| Change in the percentage of body fat of body composition |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Valeria JY Chiu, MD | Taipei Tzu Chi Hospital, Buddhist Tzu Chi Foundation | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16509530 | Result | Schlumpf M, Eiholzer U, Gygax M, Schmid S, van der Sluis I, l'Allemand D. A daily comprehensive muscle training programme increases lean mass and spontaneous activity in children with Prader-Willi syndrome after 6 months. J Pediatr Endocrinol Metab. 2006 Jan;19(1):65-74. doi: 10.1515/jpem.2006.19.1.65. | |
| 12520259 | Result |
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| ID | Term |
|---|---|
| D011218 | Prader-Willi Syndrome |
| ID | Term |
|---|---|
| D008607 | Intellectual Disability |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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Regional percentage body fat (%)
| Change from Baseline body composition components at 6 months |
| Change in the body fat mass of body composition | Fat mass (kg) | Change from Baseline body composition components at 6 months |
| Change in the lean body mass of body composition | Lean body mass (kg) | Change from Baseline body composition components at 6 months |
| Eiholzer U, Nordmann Y, l'Allemand D, Schlumpf M, Schmid S, Kromeyer-Hauschild K. Improving body composition and physical activity in Prader-Willi Syndrome. J Pediatr. 2003 Jan;142(1):73-8. doi: 10.1067/mpd.2003.mpd0334. |
| D000015 | Abnormalities, Multiple |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D025063 | Chromosome Disorders |
| D030342 | Genetic Diseases, Inborn |
| D000096803 | Imprinting Disorders |
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |