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Using isochronous maps during radiofrequency ablation procedures may identify the driver zones responsible for atrial fibrillation maintenance with greater accuracy compared to a conventional procedure (simple antral isolation of the associated pulmonary veins or, if necessary, combined with removal of spatio-temporal dispersal zones) that do not use isochronous maps, and thus improve the efficiency and safety of atrial fibrillation treatment by radiofrequency treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | ablation of Atrial fibrillation using spatio-temporal dispersion |
|
| Isochrone | Experimental | ablation of concordance zones using isochrone and voltage maps |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Atrial fibrillation ablation | Procedure | ablation of Atrial fibrillation using spatio-temporal dispersion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Atrial fibrillation relapse between groups | Atrial fibrillation detected by routine or event-associated Holter examination | Month 18 |
| Measure | Description | Time Frame |
|---|---|---|
| Atrial fibrillation relapse between groups | Atrial fibrillation detected by routine or event-associated Holter examination | Month 12 |
| Arrhythmia occurrence between groups | Arrhythmia, including atrial tachycardia detected by routine or event-associated Holter examination |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Montpellier | Montpellier | 34295 | France | |||
| CHU Nimes |
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| Atrial fibrillation ablation | Procedure | ablation of concordance zones using isochrone and voltage maps |
|
| Month 12 |
| Arrhythmia occurrence between groups | Arrhythmia, including atrial tachycardia detected by routine or event-associated Holter examination | Month 18 |
| Concordance of isochrone and voltage maps | Binary yes/no | Day 0 |
| Maximum variation of conduction speed between variation healthy zones with anisochronic zones in the same anatomic region | Day 0 |
| Comparison of the decreasing velocities between healthy zones and anisochronic zones in the same anatomic region | Day 0 |
| Comparison of wave front rotation between healthy zones and anisochronic zones in the same anatomic region | degrees | Day 0 |
| Total time of radiofrequency between groups | Minutes | Day 0 |
| Comparison of lesion volume between groups | Force-time integral, lesion size index or stroke volume index | Day 0 |
| Total procedure time between groups | Minutes | Day 0 |
| Number of treated zones between groups | Day 0 |
| Size of treated zones between groups | cm2 | Day 0 |
| List locations most frequently treated | Number of each | Day 0 |
| Survival without relapse of the subgroups paroxysmal versus persistent atrial fibrillation. | Atrial fibrillation detected by routine or event-associated Holter examination | Month 18 |
| Survival without relapse of the subgroups treated using the Carto- vs Rhythmia-guided ablation approaches. | Atrial fibrillation detected by routine or event-associated Holter examination | Month 18 |
| Nîmes |
| 30029 |
| France |
| ID | Term |
|---|---|
| D001281 | Atrial Fibrillation |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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