FMT in the Treatment of IBS

FECAL MICROBIOTA TRANSPLANTATION IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME

52 adult IBS patients were recruited. 50% were given a fecal microbiota transplantation in colonoscopy and 50% were given an FMT made of their own feces as placebo. follow up time was 1 year after FMT.

52 adult IBS patients of any subgroup(IBS-D, IBS-C or IBS-M), were recruited and given an FMT in colonoscopy. Neither the patient nor the care taking personnel did know in which group the patients belonged to. The patients were screened with fecal samples for 16RNA sequencing and they were repeatedly done IBS-SSS questionnaire and questionnaires for quality of life and psychical condition. Follow up time was 1 year after the colonoscopy.

Inclusion Criteria:

• Diagnosis of IBS based on Rome III criteria
• Having received traditional treatment for at least 1 month
• Availability of consecutive fecal samples over one year.
• Compliance to attend ileocolonoscopy and FMT procedure.
• 18-75 years

Exclusion Criteria:

• Unable to provide informed consent
• Antibiotic therapy in past 3 months
• Inflammatory bowel disease (IBD)